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- W2949649453 abstract "Background Disease activity often improves during pregnancy and worsens at the postpartum period [1]. The long-term effect of pregnancy on radiographic joint damage progression among premenopausal women with RA has been barely studied. Objectives The aim of this study was to analyse the impact of pregnancy on radiographic progression in premenopausal women with RA. Methods This is an observational cohort study of RA patients included in the Swiss Clinical Quality Management in Rheumatoid Arthritis (SCQM-RA). Patients enrolled are followed-up yearly and have radiographic assessments at regular intervals. Information about female reproductive factors, such as pregnancies, breastfeeding and hormonal treatment were retrospectively retrieved using a questionnaire. For this analysis we included premenopausal women with at least two radiographic assessment and full information on reproductive factors. The primary outcome was the rate of radiographic progression (Ratingen erosion score). We analysed the radiographic progression between premenopausal women with at least one pregnancy and those with no pregnancies. Baseline time was the first radiographic assessment. We used a multilevel regression model for longitudinal data, adjusted for potential confounders, such as baseline age, disease duration, DAS-28 and treatment. Results Among 1966 women who were interviewed, 430 premenopausal women with sequential radiographic assessments during follow-up were analysed. Half of premenopausal women had at least one pregnancy. Women with at least one pregnancy were older than nulliparous (median of 41 vs 36 years, p Conclusion In premenopausal women with RA, joint damage progressed more rapidly in nulliparous women than in women with at least one pregnancy. However, we cannot make any definite causal inference, since it is well possible that women renouncing getting pregnant might be patients with more severe disease. Radiographic progression appeared to increase the longer the time since pregnancy. References [1] Ince-Askan H, et al. J Rheumatol2016;43 :22-5. Disclosure of Interests Deshire Alpizar-Rodriguez: None declared, Frauke Forger: None declared, Axel Finckh Grant/research support from: Bristol-Myers Squibb, Pfizer Inc, Consultant for: AbbVie, A2Bio, Bristol-Myers Squibb, MSD, Roche, Pfizer Inc, and UCB" @default.
- W2949649453 created "2019-06-27" @default.
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- W2949649453 date "2019-06-01" @default.
- W2949649453 modified "2023-09-23" @default.
- W2949649453 title "FRI0655 THE IMPACT OF PREGNANCY ON STRUCTURAL PROGRESSION IN PREMENOPAUSAL WOMEN WITH RHEUMATOID ARTHRITIS" @default.
- W2949649453 doi "https://doi.org/10.1136/annrheumdis-2019-eular.4673" @default.
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