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- W2949650629 abstract "A series of thiazole-4-carboxylic acid thiazol-2-ylamide (TCAT, 4) derivatives were designed and synthesized according to simple bioisosteric replacement from previously reported pyridine-2-carboxylic acid thiazol-2-ylamide (PCAT) MetAP inhibitors. The preliminary SAR studies demonstrated that these TCAT series of compounds showed different activity and selectivity compared with those of the corresponding PCAT compounds. These findings provide useful information for the design and discovery of more potent inhibitors of type I MetAPs." @default.
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- W2949650629 date "2006-01-31" @default.
- W2949650629 modified "2023-10-18" @default.
- W2949650629 title "Identification of Potent Type I MetAP Inhibitors by Simple Bioisosteric Replacement. Part 1. Synthesis and Preliminary SAR Studies of Thiazole-4-carboxylic Acid Thiazol-2-ylamide Derivatives." @default.
- W2949650629 cites W2168968864 @default.
- W2949650629 doi "https://doi.org/10.1002/chin.200605231" @default.
- W2949650629 hasPublicationYear "2006" @default.
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