Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949661938> ?p ?o ?g. }
- W2949661938 abstract "SUMMARY Antibiotics can induce mutations that cause antibiotic resistance. Yet, despite their importance, mechanisms of antibiotic-promoted mutagenesis remain elusive. We report that the fluoroquinolone antibiotic ciprofloxacin (cipro) induces mutations that cause drug resistance by triggering differentiation of a mutant-generating cell subpopulation, using reactive oxygen species (ROS) to signal the sigma-S (σ S ) general-stress response. Cipro-generated DNA breaks activate the SOS DNA-damage response and error-prone DNA polymerases in all cells. However, mutagenesis is restricted to a cell subpopulation in which electron transfer and SOS induce ROS, which activate the σ S response, allowing mutagenesis during DNA-break repair. When sorted, this small σ S -response-“on” subpopulation produces most antibiotic cross-resistant mutants. An FDA-approved drug prevents σ S induction specifically inhibiting antibiotic-promoted mutagenesis. Furthermore, SOS-inhibited cell division, causing multi-chromosome cells, is required for mutagenesis. The data support a model in which within-cell chromosome cooperation together with development of a “gambler” cell subpopulation promote resistance evolution without risking most cells." @default.
- W2949661938 created "2019-06-27" @default.
- W2949661938 creator A5000421887 @default.
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- W2949661938 creator A5089758234 @default.
- W2949661938 date "2018-12-11" @default.
- W2949661938 modified "2023-09-28" @default.
- W2949661938 title "Gamblers: an Antibiotic-induced Evolvable Cell Subpopulation Differentiated by Reactive-oxygen-induced General Stress Response" @default.
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