FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949662203> ?p ?o ?g. }

• W2949662203 abstract "The basic helix-loop-helix (bHLH) family of transcription factors is one of the largest superfamilies of regulatory transcription factors and is widely used in eukaryotic organisms. They play an essential role in a range of metabolic, physiological, and developmental processes, including the development of the nervous system (NS). These transcription factors have been studied in many metazoans, especially in vertebrates but also in early branching metazoan clades such as the cnidarians and sponges. However, currently very little is known about their expression in the most basally branching bilaterian group, the xenacoelomorphs. Recently, our laboratory has characterized the full complement of bHLH in the genome of two members of the Xenacoelomorpha, the xenoturbellid Xenoturbella bocki and the acoel Symsagittifera roscoffensis. Understanding the patterns of bHLH gene expression in members of this phylum (in space and time) provides critical new insights into the conserved roles of the bHLH and their putative specificities in this group. Our focus is on deciphering the specific roles that these genes have in the process of neurogenesis.Here, we analyze the developmental expression of the whole complement of bHLH genes identified in the acoel S. roscoffensis. Based on their expression patterns, several members of bHLH class A appear to have specific conserved roles in neurogenesis, while other class A genes (as well as members of other classes) have likely taken on more generalized functions. All gene expression patterns are described in embryos and early juveniles.Our results suggest that the main roles of the bHLH genes of S. roscoffensis are evolutionarily conserved, with a specific subset dedicated to patterning the nervous system: SrAscA, SrAscB, SrHes/Hey, SrNscl, SrSrebp, SrE12/E47 and SrOlig." @default.
• W2949662203 created "2019-06-27" @default.
• W2949662203 creator A5026153993 @default.
• W2949662203 creator A5050273913 @default.
• W2949662203 creator A5071362153 @default.
• W2949662203 date "2018-03-29" @default.
• W2949662203 modified "2023-10-12" @default.
• W2949662203 title "Characterization of the bHLH family of transcriptional regulators in the acoel S. roscoffensis and their putative role in neurogenesis" @default.
• W2949662203 cites W11759780 @default.
• W2949662203 cites W1502547260 @default.
• W2949662203 cites W1551331657 @default.
• W2949662203 cites W1865896332 @default.
• W2949662203 cites W1900858390 @default.
• W2949662203 cites W1967924545 @default.
• W2949662203 cites W1973082043 @default.
• W2949662203 cites W1975203903 @default.
• W2949662203 cites W1975389069 @default.
• W2949662203 cites W1977134311 @default.
• W2949662203 cites W1980517461 @default.
• W2949662203 cites W1980834269 @default.
• W2949662203 cites W1985738221 @default.
• W2949662203 cites W1987084599 @default.
• W2949662203 cites W1988011675 @default.
• W2949662203 cites W1988190707 @default.
• W2949662203 cites W1990260710 @default.
• W2949662203 cites W1995635569 @default.
• W2949662203 cites W1998398072 @default.
• W2949662203 cites W2014666371 @default.
• W2949662203 cites W2016053029 @default.
• W2949662203 cites W2016559834 @default.
• W2949662203 cites W2021331463 @default.
• W2949662203 cites W2021614839 @default.
• W2949662203 cites W2027035529 @default.
• W2949662203 cites W2034949556 @default.
• W2949662203 cites W2037968599 @default.
• W2949662203 cites W2043655216 @default.
• W2949662203 cites W2045706814 @default.
• W2949662203 cites W2056069458 @default.
• W2949662203 cites W2056577696 @default.
• W2949662203 cites W2058817551 @default.
• W2949662203 cites W2061183445 @default.
• W2949662203 cites W2068976751 @default.
• W2949662203 cites W2069793235 @default.
• W2949662203 cites W2072769447 @default.
• W2949662203 cites W2082807347 @default.
• W2949662203 cites W2087106852 @default.
• W2949662203 cites W2088176129 @default.
• W2949662203 cites W2091496842 @default.
• W2949662203 cites W2091856237 @default.
• W2949662203 cites W2097085648 @default.
• W2949662203 cites W2099540110 @default.
• W2949662203 cites W2100886237 @default.
• W2949662203 cites W2108650715 @default.
• W2949662203 cites W2110269510 @default.
• W2949662203 cites W2112738731 @default.
• W2949662203 cites W2116526344 @default.
• W2949662203 cites W2118744236 @default.
• W2949662203 cites W2119483052 @default.
• W2949662203 cites W2125920059 @default.
• W2949662203 cites W2128464557 @default.
• W2949662203 cites W2131519881 @default.
• W2949662203 cites W2133899877 @default.
• W2949662203 cites W2135306983 @default.
• W2949662203 cites W2138122982 @default.
• W2949662203 cites W2142397827 @default.
• W2949662203 cites W2143654291 @default.
• W2949662203 cites W2146314565 @default.
• W2949662203 cites W2155082284 @default.
• W2949662203 cites W2155925660 @default.
• W2949662203 cites W2155994496 @default.
• W2949662203 cites W2156120549 @default.
• W2949662203 cites W2158499654 @default.
• W2949662203 cites W2160378721 @default.
• W2949662203 cites W2160819955 @default.
• W2949662203 cites W2161695267 @default.
• W2949662203 cites W2164316007 @default.
• W2949662203 cites W2172007165 @default.
• W2949662203 cites W2177494588 @default.
• W2949662203 cites W2191648353 @default.
• W2949662203 cites W2267531769 @default.
• W2949662203 cites W2292108018 @default.
• W2949662203 cites W2413445654 @default.
• W2949662203 cites W2441086403 @default.
• W2949662203 cites W2529956550 @default.
• W2949662203 cites W2748708429 @default.
• W2949662203 cites W2769399124 @default.
• W2949662203 cites W2774307240 @default.
• W2949662203 cites W2974991955 @default.
• W2949662203 cites W4234347884 @default.
• W2949662203 doi "https://doi.org/10.1186/s13227-018-0097-y" @default.
• W2949662203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5875013" @default.
• W2949662203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29610658" @default.
• W2949662203 hasPublicationYear "2018" @default.
• W2949662203 type Work @default.
• W2949662203 sameAs 2949662203 @default.
• W2949662203 citedByCount "10" @default.
• W2949662203 countsByYear W29496622032018 @default.
• W2949662203 countsByYear W29496622032019 @default.
• W2949662203 countsByYear W29496622032020 @default.
• W2949662203 countsByYear W29496622032021 @default.

• next