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• W2949662337 abstract "Engineering of the skeletal muscles has attracted attention for the restoration of damaged muscles from myopathy, injury, and extraction of malignant tumors. Reconstructing a three-dimensional muscle using living cells could be a promising approach. However, the regenerated tissue exhibits a weak construction force due to the insufficient tissue maturation. The purpose of this study is to establish the reconstruction system for the skeletal muscle. We used a cell-laden core-shell hydrogel microfiber as a three-dimensional culture to control the cellular orientation. Moreover, to mature the muscle tissue in the microfiber, we also developed a custom-made culture device for imposing cyclic stretch stimulation using a motorized stage and the fiber-grab system. As a result, the directions of the myotubes were oriented and the mature myotubes could be formed by cyclic stretch stimulation." @default.
• W2949662337 created "2019-06-27" @default.
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• W2949662337 date "2019-06-15" @default.
• W2949662337 modified "2023-10-09" @default.
• W2949662337 title "Effect of Cyclic Stretch on Tissue Maturation in Myoblast-Laden Hydrogel Fibers" @default.
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• W2949662337 doi "https://doi.org/10.3390/mi10060399" @default.
• W2949662337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6630375" @default.
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