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• W2949668712 abstract "The aim of the study was to find out the probable effect of the comorbid flow of nonalcoholic steatohepatitis on the functional state of the kidneys and the activity of inflammation of the kidneys in patients with chronic kidney disease (pyelonephritis) of the I–III stages, to determine the pathogenetic role of endothelial dysfunction, lipid distress syndrome, endotoxicosis and oxidative stress in the mechanisms of their mutual burden.Material and methods. 240 patients with chronic kidney disease (chronic bilateral peylonephritis) of the I–III stages were examined, 145 of which had comorbid nonalcoholic steatohepatitis and obesity of the 1st degree (group 1), 95 patients were diagnosed with stages I–III of chronic kidney disease stages without comorbid pathology. Depending on the stage of the chronic kidney disease, both groups were divided as follows: the 1st group — into 3 subgroups: 51 patients with stage 1 of chronic kidney disease, 53 patients with stage 2 of chronic kidney disease, 41 patients with stage 3 of chronic kidney disease. The 2nd group was divided into 3 subgroups: 32 patients with stage 1 of chronic kidney disease, 35 patients with stage 2 of chronic kidney disease, 28 patients with stage 3 of chronic kidney disease. The control group consisted of 30 practically healthy persons.Results. As a result of the research it was established that nonalcoholic steatohepatitis affects the functional state of the kidneys in patients with stages I–III of chronic kidney disease І-ІІІ stages with a possible reduction of nitrogen function, velocity of glomerular filtration, increase in the intensity of hypoalbuminemia, proteinuria, leukocyturia, erythrocyturia, cylinduria, bacteriuria than in isolated course of chronic kidney disease.Conclusions. For the comorbidity of the chronic kidney disease with nonalcoholic steatohepatitis and a decrease in glomerular filtration rate, an increase in the intensity of oxidative stress, endotoxicosis, lipid distress syndrome, degree of violation of the functional state of the endothelium: increased activity of iNOS, nitrite/nitrate content, endothelin‑1, homocysteine, cytokeratin‑18, decrease in the activity of arginase, H2S content, which correlate with the intermediate and high power interactions with the index of glomerular filtration rate." @default.
• W2949668712 created "2019-06-27" @default.
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• W2949668712 date "2018-12-30" @default.
• W2949668712 modified "2023-10-18" @default.
• W2949668712 title "Renal functional status and inflammation activity in patients with chronic kidney disease and nonalcoholic steatohepatitis on the background of obesity" @default.
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• W2949668712 doi "https://doi.org/10.24061/2413-0737.xxii.4.88.2018.80" @default.
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