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• W2949674663 startingPage "69" @default.
• W2949674663 abstract "Macrocyclic lactone (ML) anthelmintics are the most important class of anthelmintics because of our high dependence on them for the control of nematode parasites and some ectoparasites in livestock, companion animals and in humans. However, resistance to MLs is of increasing concern. Resistance is commonplace throughout the world in nematode parasites of small ruminants and is of increasing concern in horses, cattle, dogs and other animals. It is suspected in Onchocerca volvulus in humans. In most animals, resistance first arose to the avermectins, such as ivermectin (IVM), and subsequently to moxidectin (MOX). Usually when parasite populations are ML-resistant, MOX is more effective than avermectins. MOX may have higher intrinsic potency against some parasites, especially filarial nematodes, than the avermectins. However, it clearly has a significantly different pharmacokinetic profile. It is highly distributed to lipid tissues, less likely to be removed by ABC efflux transporters, is poorly metabolized and has a long half-life. This results in effective concentrations persisting for longer in target hosts. It also has a high safety index. Limited data suggest that anthelmintic resistance may be overcome, at least temporarily, if a high concentration can be maintained at the site of the parasites for a prolonged period of time. Because of the properties of MOX, there are reasonable prospects that strains of parasites that are resistant to avermectins at currently recommended doses will be controlled by MOX if it can be administered at sufficiently high doses and in formulations that enhance its persistence in the host. This review examines the properties of MOX that support this contention and compares them with the properties of other MLs. The case for using MOX to better control ML-resistant parasites is summarised and some outstanding research questions are presented." @default.
• W2949674663 created "2019-06-27" @default.
• W2949674663 creator A5061975016 @default.
• W2949674663 creator A5073368410 @default.
• W2949674663 date "2019-08-01" @default.
• W2949674663 modified "2023-10-14" @default.
• W2949674663 title "Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance" @default.
• W2949674663 cites W127621821 @default.
• W2949674663 cites W132231329 @default.
• W2949674663 cites W1546325539 @default.
• W2949674663 cites W1757271791 @default.
• W2949674663 cites W1871123198 @default.
• W2949674663 cites W1947875388 @default.
• W2949674663 cites W1964644685 @default.
• W2949674663 cites W1967285730 @default.
• W2949674663 cites W1968176674 @default.
• W2949674663 cites W1968208599 @default.
• W2949674663 cites W1969940233 @default.
• W2949674663 cites W1972677005 @default.
• W2949674663 cites W1975239375 @default.
• W2949674663 cites W1977584573 @default.
• W2949674663 cites W1978584100 @default.
• W2949674663 cites W1979822461 @default.
• W2949674663 cites W1982133489 @default.
• W2949674663 cites W1983518163 @default.
• W2949674663 cites W1983849953 @default.
• W2949674663 cites W1984447784 @default.
• W2949674663 cites W1984476204 @default.
• W2949674663 cites W1984603758 @default.
• W2949674663 cites W1985616069 @default.
• W2949674663 cites W1986642983 @default.
• W2949674663 cites W1991060599 @default.
• W2949674663 cites W1992109253 @default.
• W2949674663 cites W1994271718 @default.
• W2949674663 cites W1997028209 @default.
• W2949674663 cites W1997680903 @default.
• W2949674663 cites W2001576023 @default.
• W2949674663 cites W2002861734 @default.
• W2949674663 cites W2003446114 @default.
• W2949674663 cites W2006391573 @default.
• W2949674663 cites W2007700575 @default.
• W2949674663 cites W2009253578 @default.
• W2949674663 cites W2011226665 @default.
• W2949674663 cites W2012727279 @default.
• W2949674663 cites W2013019759 @default.
• W2949674663 cites W2013333615 @default.
• W2949674663 cites W2014391366 @default.
• W2949674663 cites W2014451346 @default.
• W2949674663 cites W2014675170 @default.
• W2949674663 cites W2015519080 @default.
• W2949674663 cites W2017410078 @default.
• W2949674663 cites W2017678442 @default.
• W2949674663 cites W2017680520 @default.
• W2949674663 cites W2018753422 @default.
• W2949674663 cites W2018998736 @default.
• W2949674663 cites W2019303799 @default.
• W2949674663 cites W2019454741 @default.
• W2949674663 cites W2022908748 @default.
• W2949674663 cites W2024619143 @default.
• W2949674663 cites W2025719249 @default.
• W2949674663 cites W2026236375 @default.
• W2949674663 cites W2030252570 @default.
• W2949674663 cites W2036455421 @default.
• W2949674663 cites W2038293434 @default.
• W2949674663 cites W2038317763 @default.
• W2949674663 cites W2038638853 @default.
• W2949674663 cites W2040522014 @default.
• W2949674663 cites W2040916999 @default.
• W2949674663 cites W2043074132 @default.
• W2949674663 cites W2051287762 @default.
• W2949674663 cites W2052538874 @default.
• W2949674663 cites W2053773186 @default.
• W2949674663 cites W2054379174 @default.
• W2949674663 cites W2057894842 @default.
• W2949674663 cites W2058348572 @default.
• W2949674663 cites W2058515521 @default.
• W2949674663 cites W2063851886 @default.
• W2949674663 cites W2064745707 @default.
• W2949674663 cites W2065813362 @default.
• W2949674663 cites W2068878070 @default.
• W2949674663 cites W2070260104 @default.
• W2949674663 cites W2070397171 @default.
• W2949674663 cites W2072780759 @default.
• W2949674663 cites W2076210901 @default.
• W2949674663 cites W2077740759 @default.
• W2949674663 cites W2082216843 @default.
• W2949674663 cites W2085069735 @default.
• W2949674663 cites W2089432070 @default.
• W2949674663 cites W2090402915 @default.
• W2949674663 cites W2090835998 @default.
• W2949674663 cites W2091054557 @default.
• W2949674663 cites W2091914833 @default.
• W2949674663 cites W2092320439 @default.
• W2949674663 cites W2093119139 @default.
• W2949674663 cites W2099365945 @default.
• W2949674663 cites W2099542873 @default.
• W2949674663 cites W2102990715 @default.
• W2949674663 cites W2110645609 @default.

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