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- W2949697576 abstract "Subtypes of nucleus accumbens medium spiny neurons (MSNs) promote dichotomous outcomes in motivated behaviors. However, recent reports indicate enhancing activity of either nucleus accumbens (NAc) core MSN subtype augments reward, suggesting coincident MSN activity may underlie this outcome. Here, we report a collateral excitation mechanism in which high-frequency, NAc core dopamine 1 (D1)-MSN activation causes long-lasting potentiation of excitatory transmission (LLP) on dopamine receptor 2 (D2)-MSNs. Our mechanistic investigation demonstrates that this form of plasticity requires release of the excitatory peptide substance P from D1-MSNs and robust cholinergic interneuron activation through neurokinin receptor stimulation. We also reveal that D2-MSN LLP requires muscarinic 1 receptor activation, intracellular calcium signaling, and GluR2-lacking AMPAR insertion. This study uncovers a mechanism for shaping NAc core activity through the transfer of excitatory information from D1-MSNs to D2-MSNs and may provide a means for altering goal-directed behavior through coordinated MSN activity." @default.
- W2949697576 created "2019-06-27" @default.
- W2949697576 creator A5045219347 @default.
- W2949697576 creator A5065178862 @default.
- W2949697576 creator A5069079438 @default.
- W2949697576 creator A5087568242 @default.
- W2949697576 creator A5087966982 @default.
- W2949697576 date "2019-08-01" @default.
- W2949697576 modified "2023-10-15" @default.
- W2949697576 title "High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs" @default.
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- W2949697576 doi "https://doi.org/10.1016/j.neuron.2019.05.031" @default.
- W2949697576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6712577" @default.
- W2949697576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31221559" @default.
- W2949697576 hasPublicationYear "2019" @default.