FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949742490> ?p ?o ?g. }

• W2949742490 abstract "Our previous studies showed that ZBTB7A played an important role in promoting nasopharyngeal carcinoma (NPC) progression. However, molecular mechanisms of different levels of ZBTB7A are still unclear. It is necessary to search molecular markers which are closely connected with ZBTB7A. We selected NPC sublines CNE2 with stably transfecting empty plasmid (negative control, NC) and short hair RNA (shRNA) plasmid targeting ZBTB7A as research objectives. Microarray was used to screen differentially expressed long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) via shRNA-CNE2 versus NC-CNE2. Quantitative PCR (qPCR) was used to validate lncRNAs and mRNAs from the sublines, chronic rhinitis, and NPC tissues. Bioinformatics was used to analyze regulatory pathways which were connected with ZBTB7A. The 1501 lncRNAs (long noncoding RNAs) and 1275 differentially expressed mRNAs were upregulated or downregulated over 2-fold. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the upregulated or downregulated carbohydrate and lipid metabolisms probably involved in carcinogenicity of shRNA-CNE2 (P-value cut-off was 0.05). In order to find the molecular mechanisms of ZBTB7A, we validated 12 differentially expressed lncRNAs and their nearby mRNAs by qPCR. Most of the differentially expressed mRNAs are closely connected with carbohydrate and lipid metabolisms in multiply cancers. Furthermore, part of them were validated in NPC and rhinitis tissues by qPCR. As a result, NR_047538, ENST00000442852, and fatty acid synthase (FASN) were closely associated with NPC. ZBTB7A had a positive association with NR_047538 and negative associations with ENST00000442852 and FASN. The results probably provide novel candidate biomarkers for NPC progression with different levels of ZBTB7A." @default.
• W2949742490 created "2019-06-27" @default.
• W2949742490 creator A5001495269 @default.
• W2949742490 creator A5004685062 @default.
• W2949742490 creator A5013721021 @default.
• W2949742490 creator A5016887977 @default.
• W2949742490 creator A5025738678 @default.
• W2949742490 creator A5033351070 @default.
• W2949742490 creator A5035506015 @default.
• W2949742490 creator A5042655328 @default.
• W2949742490 creator A5048575345 @default.
• W2949742490 creator A5056710937 @default.
• W2949742490 creator A5064065903 @default.
• W2949742490 creator A5074131698 @default.
• W2949742490 creator A5079604756 @default.
• W2949742490 creator A5083581319 @default.
• W2949742490 creator A5084593226 @default.
• W2949742490 creator A5087544706 @default.
• W2949742490 date "2019-06-11" @default.
• W2949742490 modified "2023-10-12" @default.
• W2949742490 title "Long Noncoding RNAs and Messenger RNAs Expression Profiles Potentially Regulated by ZBTB7A in Nasopharyngeal Carcinoma" @default.
• W2949742490 cites W102993097 @default.
• W2949742490 cites W1477783513 @default.
• W2949742490 cites W1685280444 @default.
• W2949742490 cites W1897146833 @default.
• W2949742490 cites W1925007159 @default.
• W2949742490 cites W1968017437 @default.
• W2949742490 cites W1978575705 @default.
• W2949742490 cites W1979662111 @default.
• W2949742490 cites W1988728967 @default.
• W2949742490 cites W1998310906 @default.
• W2949742490 cites W2008725630 @default.
• W2949742490 cites W2019735166 @default.
• W2949742490 cites W2033250049 @default.
• W2949742490 cites W2038036687 @default.
• W2949742490 cites W2039047093 @default.
• W2949742490 cites W2053699199 @default.
• W2949742490 cites W2055794899 @default.
• W2949742490 cites W2069016182 @default.
• W2949742490 cites W2071082864 @default.
• W2949742490 cites W2071271349 @default.
• W2949742490 cites W2075152467 @default.
• W2949742490 cites W2087256513 @default.
• W2949742490 cites W2095214470 @default.
• W2949742490 cites W2095476357 @default.
• W2949742490 cites W2096303392 @default.
• W2949742490 cites W2104628579 @default.
• W2949742490 cites W2105461519 @default.
• W2949742490 cites W2113846605 @default.
• W2949742490 cites W2121772485 @default.
• W2949742490 cites W2122492739 @default.
• W2949742490 cites W2133439695 @default.
• W2949742490 cites W2134033103 @default.
• W2949742490 cites W2143571269 @default.
• W2949742490 cites W2160312435 @default.
• W2949742490 cites W2160333540 @default.
• W2949742490 cites W2165079288 @default.
• W2949742490 cites W2171640413 @default.
• W2949742490 cites W2173811814 @default.
• W2949742490 cites W2195480999 @default.
• W2949742490 cites W2258043019 @default.
• W2949742490 cites W2265596009 @default.
• W2949742490 cites W2285772650 @default.
• W2949742490 cites W2296474859 @default.
• W2949742490 cites W2296606837 @default.
• W2949742490 cites W2302157033 @default.
• W2949742490 cites W2322098824 @default.
• W2949742490 cites W2323621372 @default.
• W2949742490 cites W2326704285 @default.
• W2949742490 cites W2415854929 @default.
• W2949742490 cites W2465379473 @default.
• W2949742490 cites W2470928691 @default.
• W2949742490 cites W2512804330 @default.
• W2949742490 cites W2519528904 @default.
• W2949742490 cites W2550448147 @default.
• W2949742490 cites W2553677952 @default.
• W2949742490 cites W2566054465 @default.
• W2949742490 cites W2573749620 @default.
• W2949742490 cites W2579978896 @default.
• W2949742490 cites W2588872218 @default.
• W2949742490 cites W2606660292 @default.
• W2949742490 cites W2623614656 @default.
• W2949742490 cites W2733953247 @default.
• W2949742490 cites W2742020244 @default.
• W2949742490 cites W2743156043 @default.
• W2949742490 cites W2744796035 @default.
• W2949742490 cites W2756866387 @default.
• W2949742490 cites W2758097371 @default.
• W2949742490 cites W2769749509 @default.
• W2949742490 cites W2778809586 @default.
• W2949742490 cites W2785085106 @default.
• W2949742490 cites W2791874567 @default.
• W2949742490 cites W2801430015 @default.
• W2949742490 cites W2802483635 @default.
• W2949742490 cites W2804937140 @default.
• W2949742490 cites W2811011737 @default.
• W2949742490 cites W2886104115 @default.
• W2949742490 cites W2890324818 @default.
• W2949742490 cites W2911881797 @default.
• W2949742490 cites W2912517046 @default.

• next