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- W2949744030 abstract "A range of polyether para-substituted phosphoramidates were synthesised and found to have substantially elevated aqueous solubilities compared to the underivatised parent prodrug. A 30-fold increase in aqueous solubility could be achieved without a substantial decrease of in vitro activity against HIV-1. Replacement of the aryl (i.e. phenolic) moiety by tyrosine led to a substantial enhancement in aqueous solubility but also to a decrease in antiviral potency. A previously unobserved trend was identified, relating increased aryl substituent steric bulk to decreased antiviral activity." @default.
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- W2949744030 date "2010-06-08" @default.
- W2949744030 modified "2023-09-25" @default.
- W2949744030 title "ChemInform Abstract: Enhancing the Aqueous Solubility of d4T-Based Phosphoramidate Prodrugs." @default.
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- W2949744030 doi "https://doi.org/10.1002/chin.200022198" @default.
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