Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949751711> ?p ?o ?g. }
- W2949751711 abstract "Clinical observations and accumulating laboratory evidence support a complex interplay between coagulation, inflammation, innate immunity and fibrinolysis in venous thromboembolism (VTE). VTE, which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), and the subsequent complications of post-thrombotic syndrome (PTS), are significant causes of morbidity and mortality in patients. Clinical risk factors for VTE include cancer, major trauma, surgery, sepsis, inflammatory bowel disease, paralysis, prolonged periods of immobility and aging. Abnormalities in venous blood flow or stasis initiates the activation of endothelial cells, and in concert with platelets, neutrophils and monocytes, propagates VTE in an intact vein. In addition, inflammatory cells play crucial roles in thrombus recanalization and restoration of blood flow via fibrinolysis and vascular remodeling. Faster resolution of the thrombus is key for improved disease prognosis. While in the clinical setting, anticoagulation therapy is successful in preventing propagation of venous thrombi, current therapies are not designed to inhibit inflammation, which can lead to the development of PTS. Animal models of DVT have provided many insights into the molecular and cellular mechanisms involved in the formation, propagation and resolution of venous thrombi as well as the roles of key components of the fibrinolytic system in these processes. Here, we review the recent advances in our understanding of fibrinolysis and inflammation in the resolution of VTE." @default.
- W2949751711 created "2019-06-27" @default.
- W2949751711 creator A5011313310 @default.
- W2949751711 creator A5020879336 @default.
- W2949751711 creator A5022779808 @default.
- W2949751711 creator A5027779533 @default.
- W2949751711 creator A5036203134 @default.
- W2949751711 creator A5076905861 @default.
- W2949751711 creator A5091354371 @default.
- W2949751711 date "2019-06-14" @default.
- W2949751711 modified "2023-10-16" @default.
- W2949751711 title "Fibrinolysis and Inflammation in Venous Thrombus Resolution" @default.
- W2949751711 cites W101862950 @default.
- W2949751711 cites W1481074036 @default.
- W2949751711 cites W1507606456 @default.
- W2949751711 cites W1573267684 @default.
- W2949751711 cites W15890236 @default.
- W2949751711 cites W1614733900 @default.
- W2949751711 cites W1650652405 @default.
- W2949751711 cites W1755036913 @default.
- W2949751711 cites W1836649737 @default.
- W2949751711 cites W1872409110 @default.
- W2949751711 cites W189242156 @default.
- W2949751711 cites W1900486712 @default.
- W2949751711 cites W1911450691 @default.
- W2949751711 cites W1947193815 @default.
- W2949751711 cites W1961340888 @default.
- W2949751711 cites W1965285342 @default.
- W2949751711 cites W1965708535 @default.
- W2949751711 cites W1966210924 @default.
- W2949751711 cites W1970405391 @default.
- W2949751711 cites W1971972871 @default.
- W2949751711 cites W1972706930 @default.
- W2949751711 cites W1974471520 @default.
- W2949751711 cites W1978080273 @default.
- W2949751711 cites W1978764415 @default.
- W2949751711 cites W1979408494 @default.
- W2949751711 cites W1981417802 @default.
- W2949751711 cites W1982376510 @default.
- W2949751711 cites W1983018105 @default.
- W2949751711 cites W1985642639 @default.
- W2949751711 cites W1987598636 @default.
- W2949751711 cites W1987783721 @default.
- W2949751711 cites W1989515923 @default.
- W2949751711 cites W1991243300 @default.
- W2949751711 cites W1992199903 @default.
- W2949751711 cites W1994749414 @default.
- W2949751711 cites W2001296234 @default.
- W2949751711 cites W2002354857 @default.
- W2949751711 cites W2004599468 @default.
- W2949751711 cites W2005568493 @default.
- W2949751711 cites W2007898486 @default.
- W2949751711 cites W2008123808 @default.
- W2949751711 cites W2008184120 @default.
- W2949751711 cites W2008872411 @default.
- W2949751711 cites W2011416774 @default.
- W2949751711 cites W2014569258 @default.
- W2949751711 cites W2014829368 @default.
- W2949751711 cites W2016918804 @default.
- W2949751711 cites W2016928370 @default.
- W2949751711 cites W2017657602 @default.
- W2949751711 cites W2018812222 @default.
- W2949751711 cites W2018860353 @default.
- W2949751711 cites W2019948808 @default.
- W2949751711 cites W2021165328 @default.
- W2949751711 cites W2021988356 @default.
- W2949751711 cites W2023192608 @default.
- W2949751711 cites W2025275347 @default.
- W2949751711 cites W2029383045 @default.
- W2949751711 cites W2029821653 @default.
- W2949751711 cites W2032102036 @default.
- W2949751711 cites W2032615313 @default.
- W2949751711 cites W2034224075 @default.
- W2949751711 cites W2035295151 @default.
- W2949751711 cites W2038969299 @default.
- W2949751711 cites W2044696428 @default.
- W2949751711 cites W2045220907 @default.
- W2949751711 cites W2047550984 @default.
- W2949751711 cites W2047986798 @default.
- W2949751711 cites W2052758686 @default.
- W2949751711 cites W2053608887 @default.
- W2949751711 cites W2056283605 @default.
- W2949751711 cites W2057143876 @default.
- W2949751711 cites W2058519380 @default.
- W2949751711 cites W2058842531 @default.
- W2949751711 cites W2061708424 @default.
- W2949751711 cites W2066688538 @default.
- W2949751711 cites W2067100631 @default.
- W2949751711 cites W2067143182 @default.
- W2949751711 cites W2068531894 @default.
- W2949751711 cites W2071508374 @default.
- W2949751711 cites W2072680205 @default.
- W2949751711 cites W2073429593 @default.
- W2949751711 cites W2075409030 @default.
- W2949751711 cites W2077237451 @default.
- W2949751711 cites W2079627956 @default.
- W2949751711 cites W2079845152 @default.
- W2949751711 cites W2080167098 @default.
- W2949751711 cites W2081136348 @default.
- W2949751711 cites W2084483224 @default.