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- W2949755433 abstract "Abstract The maintenance of a dynamic equilibrium between the mitochondrial and nuclear genomes requires continuous communication and a high level of compatibility between them, so that alterations in one genetic compartment need adjustments in the other. The co-evolution of nuclear and mitochondrial genomes has been poorly studied, even though the consequences and effects of this interaction are highly relevant for human health, as well as for crop improvement programs and for genetic engineering. The mitochondria of plants represent an excellent system to understand the mechanisms of genomic rearrangements, chimeric gene formation, incompatibility between nucleus and cytoplasm, and horizontal gene transfer. We carried out detailed analyses of the mitochondrial genome (mtDNA) of a repeated cybrid between the solanaceae Nicotiana tabacum and Hyoscyamus niger . The mtDNA of the cybrid was intermediate between the size of parental mtDNAs and the sum of them. Noticeably, most of the homologous sequences inherited from both parents were lost. In contrast, the majority of the sequences exclusive of a single parent were maintained. The mitochondrial gene content included a majority of N. tabacum derived genes, but also chimeric, two-parent derived, and H. niger-derived genes in a tobacco nuclear background. Any of these alterations in the gene content could be the cause of CMS in the cybrid. The parental mtDNAs interacted through 28 homologous recombination events and a single case of illegitimate recombination. Three main homologous recombination mechanisms were recognized in the cybrid mitochondria. Break induced replication (BIR) pathway was the most frequent. We propose that BIR could be one of the mechanisms responsible for the loss of the majority of the repeated regions derived from H. niger ." @default.
- W2949755433 created "2019-06-27" @default.
- W2949755433 creator A5004751019 @default.
- W2949755433 creator A5025333821 @default.
- W2949755433 creator A5029639622 @default.
- W2949755433 creator A5030386788 @default.
- W2949755433 date "2018-12-27" @default.
- W2949755433 modified "2023-10-18" @default.
- W2949755433 title "Elucidating genomic patterns and recombination events in plant cybrid mitochondria" @default.
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