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- W2949763447 abstract "A new protocol for multicomponent condensation reactions that uses fluorous (highly fluorinated) substrates is introduced. This method takes advantage of the ease of purification of fluorous compounds by liquid-liquid extractions between fluorous and organic solvents. The application of this method to the Ugi and Biginelli reactions is described. The condensation products of these two reactions, amino acid amides and dihydropyrimidines, are easily obtained without chromatography in high purities, even though the other reagents are used in very large excesses. This is the first demonstration of the suitability of fluorous phase methods for combinatorial synthesis of druglike organic molecules." @default.
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- W2949763447 date "2010-08-03" @default.
- W2949763447 modified "2023-09-25" @default.
- W2949763447 title "ChemInform Abstract: Fluorous Synthesis: Fluorous Protocols for the Ugi and Biginelli Multicomponent Condensations." @default.
- W2949763447 cites W1974800723 @default.
- W2949763447 doi "https://doi.org/10.1002/chin.199738065" @default.
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