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• W2949766020 abstract "The first and in-depth chemical investigation of the South China Sea soft coral Sinularia scabra has resulted to the isolation of a library of diverse cembrane type diterpenoids, including six new compounds, namely xiguscabrates A and B ( 1 and 2 ), xiguscabral A ( 3 ), xiguscabrols A and B ( 4 and 5 ), and 8- epi -xiguscabrol B ( 6 ), and twenty-seven known analogs ( 7 – 33 ). Their structures were elucidated by extensive spectroscopic analysis and by the comparison with literature data. In bioassay, several isolates exhibited inhibitory effects on the ConA-induced T lymphocytes and/or LPS-induced B lymphocytes proliferation. Among them, compound 24 showed considerable specific inhibition on B cell proliferation, with IC 50 value of 4.4 μ M and selectivity index (SI) of 10.9. The structure-activity relationship (SAR) of the tested metabolites was analyzed, and the further mechanism study of the specific B-cell targeted immunosuppressive compound 24 on purified CD19 + B cells was also performed to uncover the effects on the function and maturity of B cells, including cytokines production, abnormal activation, antigen presenting capacity and plasma cells formation." @default.
• W2949766020 created "2019-06-27" @default.
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• W2949766020 date "2019-08-01" @default.
• W2949766020 modified "2023-10-18" @default.
• W2949766020 title "Highly diverse cembranoids from the South China Sea soft coral Sinularia scabra as a new class of potential immunosuppressive agents" @default.
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• W2949766020 doi "https://doi.org/10.1016/j.bmc.2019.06.030" @default.
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