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- W2949773886 abstract "Despite interest in phosphoinositide (PtdIns) kinases, such as PtdIns 3 kinases (PI3K), as targets for controlling plasma membrane PtdIns levels in disease, the PtdIns have another less well-known site of action in the cell nucleus.Recent studies show that PtdIns use a variety of strategies to alter DNA responses. Here, we provide an overview of these newly identified forms of gene expression control, which should be considered when studying the therapeutic use of PtdIns-directed compounds. As PI3K is one of the most important clinical targets in recent years, we will focus on two polyphosphoinositides, the PI3K substrate PtdIns(4,5)di-phosphate (PI4,5P2) and its product PtdIns(3,4,5)tri-phosphate (PI3,4,5P3)." @default.
- W2949773886 created "2019-06-27" @default.
- W2949773886 creator A5007548000 @default.
- W2949773886 creator A5013868026 @default.
- W2949773886 creator A5057143508 @default.
- W2949773886 date "2019-01-01" @default.
- W2949773886 modified "2023-10-18" @default.
- W2949773886 title "Functions of Nuclear Polyphosphoinositides" @default.
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- W2949773886 doi "https://doi.org/10.1007/164_2019_219" @default.
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