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- W2949781623 abstract "A single copper(II)-catalyzed three-component cascade aminomethylation/cycloisomerization of propiolates to form imidazo[1,2-a]pyridines was explored. A straightforward method was developed for the practical synthesis of functionalized imidazo[1,2-a]pyridines from benzaldehydes, 2-aminopyridines, and propiolate derivatives catalyzed by Cu(OAc)2 hydrate in the presence of air. The protocol is marked by excellent yields, functional group tolerance, and, above all, adaptability to synthesize imidazo[1,2-a]pyridine-based drug molecules such as Alpidem." @default.
- W2949781623 created "2019-06-27" @default.
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- W2949781623 date "2016-02-01" @default.
- W2949781623 modified "2023-09-23" @default.
- W2949781623 title "ChemInform Abstract: Copper(II)-Mediated Aerobic Synthesis of Imidazo[1,2-a]pyridines via Cascade Aminomethylation/Cycloisomerization of Alkynes." @default.
- W2949781623 cites W2266536744 @default.
- W2949781623 doi "https://doi.org/10.1002/chin.201611184" @default.
- W2949781623 hasPublicationYear "2016" @default.
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