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- W2949792940 abstract "A small series of compounds is described in which a narrow SAR has identified N,N-dimethyl-3,4-diphenyl-1H-pyrazole-1-propanamine, 3, as a potential antidepressant with reduced side effects. The isomeric N,N-dimethyl-4,5-diphenyl-1H-pyrazole-1-propanamine was completely inactive in the primary antidepressant screens. Compounds were synthesized by Michael addition of acrylonitrile to diphenylpyrazole followed by reductive alkylation of the resultant diphenylpyrazolepropionitriles. Compound 3 was equipotent with imipramine in standard antidepressant assays in animals but showed no significant anticholinergic action and did not antagonize the antihypertensive effects of clonidine and guanethidine." @default.
- W2949792940 created "2019-06-27" @default.
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- W2949792940 date "1985-06-18" @default.
- W2949792940 modified "2023-09-25" @default.
- W2949792940 title "ChemInform Abstract: 3,4-DIPHENYL-1H-PYRAZOLE-1-PROPANAMINE ANTIDEPRESSANTS" @default.
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- W2949792940 doi "https://doi.org/10.1002/chin.198524210" @default.
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