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- W2949810366 abstract "NMR studies of stable-isotope labeled oligonucleotides have provided useful information regarding nucleic acid structures, nucleic acid - drug binding, and nucleic acid - protein interactions. For the conformational elucidation of the sugar-phosphate backbone and / or the sugar moieties in nucleic acids, 13Clabeled oligonucleotides are very useful, and for the transformation of nucleic acid - drug binding sight are 15N-labeled oligonucleotides. The present paper has introduced the recent synthetic methods of nucleosides containing either a 13C labeled sugar moiety or a 15N-labeled exocyclic amine, and applications including our research work. Keywords: Stable-isotope, exocyclic amine, sugar-phosphate backbone, Nucleosides" @default.
- W2949810366 created "2019-06-27" @default.
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- W2949810366 date "2004-07-01" @default.
- W2949810366 modified "2023-09-25" @default.
- W2949810366 title "Synthesis of Stable-isotope (13C and 15N) Labeled Nucleosides and Their Applications" @default.
- W2949810366 doi "https://doi.org/10.2174/1570193043403145" @default.
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