FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949811360> ?p ?o ?g. }

• W2949811360 abstract "Abstract NMDA receptor (NMDAR) activation is critical for maintenance and modification of synapse strength. Specifically, NMDAR activation by spontaneous glutamate release has been shown to mediate forms of synaptic plasticity as well as synaptic development. Interestingly, there is evidence that within individual synapses each release mode may be segregated such that postsynaptically there are distinct pools of responsive receptors. In order to examine potential regulators of NMDAR activation due to spontaneous glutamate release in cultured rat hippocampal neurons, we utilized GCaMP6f imaging at single synapses in concert with confocal and super-resolution imaging. Using these single spine approaches, we found that Ca 2+ entry activated by spontaneous release tends to be carried by GluN2B-NMDARs. Additionally, the amount of NMDAR activation varies greatly both between synapses and within synapses, and is unrelated to spine and synapse size, but does correlate loosely with synapse distance from the soma. Despite the critical role of spontaneous activation of NMDARs in maintaining synaptic function, their activation seems to be controlled factors other than synapse size or synapse distance from the soma. It is most likely that NMDAR activation by spontaneous release influenced variability in subsynaptic receptor position, release site position, vesicle content, and channel properties. Therefore, spontaneous activation of NMDARs appears to be regulated distinctly from other receptor types, notably AMPARs, within individual synapses. Significance Statement Understanding the underlying synaptic mechanisms for learning and memory is critically important to the field of neuroscience and for human health. A key neurotransmitter receptor type involved in learning is the NMDA receptor, and exploration of its regulation is vital. In this study, we optimized optical tools to allow detailed characterization of NMDA receptor activity at single synapses, along with analysis of structural features of the imaged synapses. The amount of receptor activation is independent of the size of the synapse, but weakly dependent on synapse position within the dendritic tree. Notably, we found that NMDA receptors activated following spontaneous neurotransmitter release tend be GluN2B-containing receptors. Thus, the unique mechanisms that regulate the number and positioning of these receptors within synapses will have important consequences for control of synaptic development and signaling." @default.
• W2949811360 created "2019-06-27" @default.
• W2949811360 creator A5029095820 @default.
• W2949811360 creator A5031820758 @default.
• W2949811360 creator A5052787173 @default.
• W2949811360 creator A5082197627 @default.
• W2949811360 date "2019-03-27" @default.
• W2949811360 modified "2023-09-23" @default.
• W2949811360 title "Properties of individual hippocampal synapses influencing NMDA-receptor activation by spontaneous neurotransmission" @default.
• W2949811360 cites W1487695731 @default.
• W2949811360 cites W1489219269 @default.
• W2949811360 cites W1505720707 @default.
• W2949811360 cites W1530479094 @default.
• W2949811360 cites W1533559637 @default.
• W2949811360 cites W1581543871 @default.
• W2949811360 cites W1597908762 @default.
• W2949811360 cites W1798313689 @default.
• W2949811360 cites W1845163922 @default.
• W2949811360 cites W1918304474 @default.
• W2949811360 cites W1952887313 @default.
• W2949811360 cites W1965265446 @default.
• W2949811360 cites W1965572014 @default.
• W2949811360 cites W1966478172 @default.
• W2949811360 cites W1966515122 @default.
• W2949811360 cites W1968024448 @default.
• W2949811360 cites W1968313665 @default.
• W2949811360 cites W1970851711 @default.
• W2949811360 cites W1973794735 @default.
• W2949811360 cites W1974467469 @default.
• W2949811360 cites W1975649337 @default.
• W2949811360 cites W1976175452 @default.
• W2949811360 cites W1976358470 @default.
• W2949811360 cites W1978458868 @default.
• W2949811360 cites W1978818962 @default.
• W2949811360 cites W1981097208 @default.
• W2949811360 cites W1983245247 @default.
• W2949811360 cites W1983553517 @default.
• W2949811360 cites W1986597140 @default.
• W2949811360 cites W1992156523 @default.
• W2949811360 cites W1993505652 @default.
• W2949811360 cites W1998916150 @default.
• W2949811360 cites W2001759117 @default.
• W2949811360 cites W2003674836 @default.
• W2949811360 cites W2007756386 @default.
• W2949811360 cites W2010926499 @default.
• W2949811360 cites W2013319759 @default.
• W2949811360 cites W2014164931 @default.
• W2949811360 cites W2015441228 @default.
• W2949811360 cites W2017241296 @default.
• W2949811360 cites W2017722024 @default.
• W2949811360 cites W2019558341 @default.
• W2949811360 cites W2020216347 @default.
• W2949811360 cites W2023238587 @default.
• W2949811360 cites W2024036641 @default.
• W2949811360 cites W2024380057 @default.
• W2949811360 cites W2030756376 @default.
• W2949811360 cites W2031779883 @default.
• W2949811360 cites W2032192786 @default.
• W2949811360 cites W2044514703 @default.
• W2949811360 cites W2045964630 @default.
• W2949811360 cites W2048142982 @default.
• W2949811360 cites W2050066016 @default.
• W2949811360 cites W2050519369 @default.
• W2949811360 cites W2052198843 @default.
• W2949811360 cites W2053361108 @default.
• W2949811360 cites W2054661844 @default.
• W2949811360 cites W2056145172 @default.
• W2949811360 cites W2060012772 @default.
• W2949811360 cites W2063541383 @default.
• W2949811360 cites W2064111585 @default.
• W2949811360 cites W2069362932 @default.
• W2949811360 cites W2072250599 @default.
• W2949811360 cites W2080640632 @default.
• W2949811360 cites W2084432365 @default.
• W2949811360 cites W2085173405 @default.
• W2949811360 cites W2086543171 @default.
• W2949811360 cites W2088307620 @default.
• W2949811360 cites W2092045031 @default.
• W2949811360 cites W2094202922 @default.
• W2949811360 cites W2096077112 @default.
• W2949811360 cites W2104147494 @default.
• W2949811360 cites W2105829350 @default.
• W2949811360 cites W2106971136 @default.
• W2949811360 cites W2117664079 @default.
• W2949811360 cites W2131270585 @default.
• W2949811360 cites W2131569072 @default.
• W2949811360 cites W2132634436 @default.
• W2949811360 cites W2132844263 @default.
• W2949811360 cites W2145791439 @default.
• W2949811360 cites W2147800368 @default.
• W2949811360 cites W2148126095 @default.
• W2949811360 cites W2148923308 @default.
• W2949811360 cites W2161093157 @default.
• W2949811360 cites W2163172571 @default.
• W2949811360 cites W2166536682 @default.
• W2949811360 cites W2167612537 @default.
• W2949811360 cites W2168234829 @default.
• W2949811360 cites W2169761872 @default.
• W2949811360 cites W2171275647 @default.
• W2949811360 cites W2178843014 @default.

• next