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• W2949836700 abstract "Pemphigus vulgaris (PV) is a rare blistering disease caused by IgG autoantibodies against the epidermal adhesion molecules desmoglein (Dsg)3 and Dsg1 providing a well-characterized paradigm of an antibody-mediated organ-specific autoimmune disease. In PV patients who have achieved clinical remission after B cell-depleting therapy, relapses often coincide with a reoccurrence of B cells and Dsg-specific autoantibodies. Here, we analyzed Dsg3-specific B cell subpopulations (i.e. total CD19+ B cells, CD19+CD27- B cells, CD19+CD27+ memory B cells, and CD19+CD27hiCD38hi plasmablasts) in peripheral blood of both PV patients (n=14) at different stages of disease and healthy individuals (n=14) by flow cytometry using fluorescently labeled recombinant human Dsg3 protein. Applying this approach, Dsg3-specific B cells could be detected at low frequencies (0.11-0.53% of CD19+ B cells) and numbers of Dsg3-specific memory B cells were signigicantly increased in PV patients in clinical remission receiving minimal immunosuppressive therapy. Finally, we confirmed in vitro that Dsg3-reactive memory B cells were able to produce anti-Dsg3 IgG autoantibodies upon ex vivo activation. Thus, monitoring of Dsg3-specific B cells in PV is of particular interest to further characterize the immunopathogenesis of PV." @default.
• W2949836700 created "2019-06-27" @default.
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• W2949836700 date "2019-06-14" @default.
• W2949836700 modified "2023-10-16" @default.
• W2949836700 title "Identification of Autoreactive B Cell Subpopulations in Peripheral Blood of Autoimmune Patients With Pemphigus Vulgaris" @default.
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• W2949836700 doi "https://doi.org/10.3389/fimmu.2019.01375" @default.
• W2949836700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6587433" @default.
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