FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949890782> ?p ?o ?g. }

• W2949890782 endingPage "465" @default.
• W2949890782 startingPage "451" @default.
• W2949890782 abstract "Abstract Mendel’s Law of equal segregation states that each of the two alleles in a diploid organism has an equal probability of being transmitted into... Meiotic drive occurs when a selfish element increases its transmission frequency above the Mendelian ratio by hijacking the asymmetric divisions of female meiosis. Meiotic drive causes genomic conflict and potentially has a major impact on genome evolution, but only a few drive loci of large effect have been described. New methods to reliably detect meiotic drive are therefore needed, particularly for discovering moderate-strength drivers that are likely to be more prevalent in natural populations than strong drivers. Here, we report an efficient method that uses sequencing of large pools of backcross (BC1) progeny to test for deviations from Mendelian segregation genome-wide with single-nucleotide polymorphisms (SNPs) that distinguish the parental strains. We show that meiotic drive can be detected by a characteristic pattern of decay in distortion of SNP frequencies, caused by recombination unlinking the driver from distal loci. We further show that control crosses allow allele-frequency distortion caused by meiotic drive to be distinguished from distortion resulting from developmental effects. We used this approach to test whether chromosomes with extreme telomere-length differences segregate at Mendelian ratios, as telomeric regions are a potential hotspot for meiotic drive due to their roles in meiotic segregation and multiple observations of high rates of telomere sequence evolution. Using four different pairings of long and short telomere strains, we find no evidence that extreme telomere-length variation causes meiotic drive in Drosophila. However, we identify one candidate meiotic driver in a centromere-linked region that shows an ∼8% increase in transmission frequency, corresponding to a ∼54:46 segregation ratio. Our results show that candidate meiotic drivers of moderate strength can be readily detected and localized in pools of BC1 progeny." @default.
• W2949890782 created "2019-06-27" @default.
• W2949890782 creator A5006834944 @default.
• W2949890782 creator A5013757864 @default.
• W2949890782 creator A5026581021 @default.
• W2949890782 creator A5038603694 @default.
• W2949890782 creator A5042307770 @default.
• W2949890782 creator A5051301807 @default.
• W2949890782 creator A5052247612 @default.
• W2949890782 creator A5060126012 @default.
• W2949890782 creator A5080506448 @default.
• W2949890782 date "2017-05-01" @default.
• W2949890782 modified "2023-10-17" @default.
• W2949890782 title "A Pooled Sequencing Approach Identifies a Candidate Meiotic Driver in <i>Drosophila</i>" @default.
• W2949890782 cites W1590964008 @default.
• W2949890782 cites W1598251074 @default.
• W2949890782 cites W1932205938 @default.
• W2949890782 cites W1972951765 @default.
• W2949890782 cites W1987871994 @default.
• W2949890782 cites W1988962165 @default.
• W2949890782 cites W2000659092 @default.
• W2949890782 cites W2003009964 @default.
• W2949890782 cites W2004923829 @default.
• W2949890782 cites W2007925676 @default.
• W2949890782 cites W20126109 @default.
• W2949890782 cites W2016461532 @default.
• W2949890782 cites W2018913450 @default.
• W2949890782 cites W2021120109 @default.
• W2949890782 cites W2029078135 @default.
• W2949890782 cites W2030299752 @default.
• W2949890782 cites W2036880391 @default.
• W2949890782 cites W2038437048 @default.
• W2949890782 cites W2038545675 @default.
• W2949890782 cites W2039770714 @default.
• W2949890782 cites W2045220576 @default.
• W2949890782 cites W2054810412 @default.
• W2949890782 cites W2059383813 @default.
• W2949890782 cites W2067244192 @default.
• W2949890782 cites W2068952113 @default.
• W2949890782 cites W2081183705 @default.
• W2949890782 cites W2091422977 @default.
• W2949890782 cites W2096250920 @default.
• W2949890782 cites W2099642610 @default.
• W2949890782 cites W2100153028 @default.
• W2949890782 cites W2101946593 @default.
• W2949890782 cites W2102619694 @default.
• W2949890782 cites W2103800899 @default.
• W2949890782 cites W2108234281 @default.
• W2949890782 cites W2110032934 @default.
• W2949890782 cites W2114025873 @default.
• W2949890782 cites W2115872416 @default.
• W2949890782 cites W2117925179 @default.
• W2949890782 cites W2118858289 @default.
• W2949890782 cites W2119180969 @default.
• W2949890782 cites W2124699023 @default.
• W2949890782 cites W2128040384 @default.
• W2949890782 cites W2131907758 @default.
• W2949890782 cites W2133257334 @default.
• W2949890782 cites W2133610661 @default.
• W2949890782 cites W2142754990 @default.
• W2949890782 cites W2152622677 @default.
• W2949890782 cites W2156176296 @default.
• W2949890782 cites W2157002105 @default.
• W2949890782 cites W2157539385 @default.
• W2949890782 cites W2159340058 @default.
• W2949890782 cites W2168133698 @default.
• W2949890782 cites W2170223694 @default.
• W2949890782 cites W2172186191 @default.
• W2949890782 cites W2280881948 @default.
• W2949890782 cites W2326165515 @default.
• W2949890782 cites W2485777128 @default.
• W2949890782 cites W2503032676 @default.
• W2949890782 cites W2550811578 @default.
• W2949890782 doi "https://doi.org/10.1534/genetics.116.197335" @default.
• W2949890782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5419488" @default.
• W2949890782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28258181" @default.
• W2949890782 hasPublicationYear "2017" @default.
• W2949890782 type Work @default.
• W2949890782 sameAs 2949890782 @default.
• W2949890782 citedByCount "47" @default.
• W2949890782 countsByYear W29498907822017 @default.
• W2949890782 countsByYear W29498907822018 @default.
• W2949890782 countsByYear W29498907822019 @default.
• W2949890782 countsByYear W29498907822020 @default.
• W2949890782 countsByYear W29498907822021 @default.
• W2949890782 countsByYear W29498907822022 @default.
• W2949890782 countsByYear W29498907822023 @default.
• W2949890782 crossrefType "journal-article" @default.
• W2949890782 hasAuthorship W2949890782A5006834944 @default.
• W2949890782 hasAuthorship W2949890782A5013757864 @default.
• W2949890782 hasAuthorship W2949890782A5026581021 @default.
• W2949890782 hasAuthorship W2949890782A5038603694 @default.
• W2949890782 hasAuthorship W2949890782A5042307770 @default.
• W2949890782 hasAuthorship W2949890782A5051301807 @default.
• W2949890782 hasAuthorship W2949890782A5052247612 @default.
• W2949890782 hasAuthorship W2949890782A5060126012 @default.
• W2949890782 hasAuthorship W2949890782A5080506448 @default.
• W2949890782 hasBestOaLocation W29498907821 @default.

• next