Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949891038> ?p ?o ?g. }
- W2949891038 endingPage "764" @default.
- W2949891038 startingPage "752" @default.
- W2949891038 abstract "ELL-associated factor 1 is a transcription elongation factor that shares significant homology and functional similarity to the androgen-responsive prostate tumor suppressor ELL-associated factor 2. EAF2 is frequently down-regulated in advanced prostate cancer and Eaf2 deletion in the mouse induced the development of murine prostatic intraepithelial neoplasia. Here we show that similar to EAF2, EAF1 is frequently down-regulated in advanced prostate cancer. Co-downregulation of EAF1 and EAF2 occurred in 40% of clinical specimens with Gleason score >7. We developed and characterized a murine model of prostate-epithelial specific deletion of Eaf1 in the prostate and crossed it with our previously generated mouse with conventional deletion of Eaf2. The prostates of Eaf1 deletion mice displayed murine prostatic intraepithelial neoplasia lesions with increased proliferation and inflammation. Combined deletion of Eaf1 and Eaf2 in the murine model induced an increased incidence in mPIN lesions characterized by increased proliferation and CD3+ T cells and CD19+ B cells infiltration compared to individual deletion of either Eaf1 or Eaf2 in the murine prostate. These results suggest that EAF1 may play a tumor suppressive role in the prostate. Cooperation between EAF1 and EAF2 may be important for prostate maintaining prostate epithelial homeostasis, and concurrent loss of these two tumor suppressors may promote prostate tumorigenesis and progression." @default.
- W2949891038 created "2019-06-27" @default.
- W2949891038 creator A5003247790 @default.
- W2949891038 creator A5017745501 @default.
- W2949891038 creator A5025664350 @default.
- W2949891038 creator A5026903972 @default.
- W2949891038 creator A5031747432 @default.
- W2949891038 creator A5033514870 @default.
- W2949891038 creator A5047637115 @default.
- W2949891038 creator A5053696763 @default.
- W2949891038 creator A5053875219 @default.
- W2949891038 creator A5058380236 @default.
- W2949891038 creator A5064478020 @default.
- W2949891038 creator A5067953338 @default.
- W2949891038 date "2019-08-01" @default.
- W2949891038 modified "2023-10-17" @default.
- W2949891038 title "Conditional Deletion of Eaf1 Induces Murine Prostatic Intraepithelial Neoplasia in Mice" @default.
- W2949891038 cites W1678580492 @default.
- W2949891038 cites W1984289421 @default.
- W2949891038 cites W1991560250 @default.
- W2949891038 cites W1995143982 @default.
- W2949891038 cites W2021755549 @default.
- W2949891038 cites W2032351323 @default.
- W2949891038 cites W2037992174 @default.
- W2949891038 cites W2065816853 @default.
- W2949891038 cites W2084693374 @default.
- W2949891038 cites W2092030652 @default.
- W2949891038 cites W2092288031 @default.
- W2949891038 cites W2099054500 @default.
- W2949891038 cites W2109496201 @default.
- W2949891038 cites W2117264216 @default.
- W2949891038 cites W2139876169 @default.
- W2949891038 cites W2141182368 @default.
- W2949891038 cites W2151214732 @default.
- W2949891038 cites W2518901523 @default.
- W2949891038 cites W2531696307 @default.
- W2949891038 cites W2584459311 @default.
- W2949891038 cites W2584469982 @default.
- W2949891038 cites W2752776294 @default.
- W2949891038 cites W2758642703 @default.
- W2949891038 cites W2761373957 @default.
- W2949891038 cites W2793503239 @default.
- W2949891038 cites W2805310495 @default.
- W2949891038 cites W2884443327 @default.
- W2949891038 cites W2913898479 @default.
- W2949891038 cites W2980804587 @default.
- W2949891038 cites W4210702584 @default.
- W2949891038 doi "https://doi.org/10.1016/j.neo.2019.05.005" @default.
- W2949891038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593215" @default.
- W2949891038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31229879" @default.
- W2949891038 hasPublicationYear "2019" @default.
- W2949891038 type Work @default.
- W2949891038 sameAs 2949891038 @default.
- W2949891038 citedByCount "5" @default.
- W2949891038 countsByYear W29498910382020 @default.
- W2949891038 countsByYear W29498910382022 @default.
- W2949891038 countsByYear W29498910382023 @default.
- W2949891038 crossrefType "journal-article" @default.
- W2949891038 hasAuthorship W2949891038A5003247790 @default.
- W2949891038 hasAuthorship W2949891038A5017745501 @default.
- W2949891038 hasAuthorship W2949891038A5025664350 @default.
- W2949891038 hasAuthorship W2949891038A5026903972 @default.
- W2949891038 hasAuthorship W2949891038A5031747432 @default.
- W2949891038 hasAuthorship W2949891038A5033514870 @default.
- W2949891038 hasAuthorship W2949891038A5047637115 @default.
- W2949891038 hasAuthorship W2949891038A5053696763 @default.
- W2949891038 hasAuthorship W2949891038A5053875219 @default.
- W2949891038 hasAuthorship W2949891038A5058380236 @default.
- W2949891038 hasAuthorship W2949891038A5064478020 @default.
- W2949891038 hasAuthorship W2949891038A5067953338 @default.
- W2949891038 hasBestOaLocation W29498910381 @default.
- W2949891038 hasConcept C121608353 @default.
- W2949891038 hasConcept C2776235491 @default.
- W2949891038 hasConcept C2776456063 @default.
- W2949891038 hasConcept C2779534503 @default.
- W2949891038 hasConcept C2780192828 @default.
- W2949891038 hasConcept C502942594 @default.
- W2949891038 hasConcept C54355233 @default.
- W2949891038 hasConcept C555283112 @default.
- W2949891038 hasConcept C86803240 @default.
- W2949891038 hasConceptScore W2949891038C121608353 @default.
- W2949891038 hasConceptScore W2949891038C2776235491 @default.
- W2949891038 hasConceptScore W2949891038C2776456063 @default.
- W2949891038 hasConceptScore W2949891038C2779534503 @default.
- W2949891038 hasConceptScore W2949891038C2780192828 @default.
- W2949891038 hasConceptScore W2949891038C502942594 @default.
- W2949891038 hasConceptScore W2949891038C54355233 @default.
- W2949891038 hasConceptScore W2949891038C555283112 @default.
- W2949891038 hasConceptScore W2949891038C86803240 @default.
- W2949891038 hasFunder F4320332161 @default.
- W2949891038 hasIssue "8" @default.
- W2949891038 hasLocation W29498910381 @default.
- W2949891038 hasLocation W29498910382 @default.
- W2949891038 hasLocation W29498910383 @default.
- W2949891038 hasLocation W29498910384 @default.
- W2949891038 hasOpenAccess W2949891038 @default.
- W2949891038 hasPrimaryLocation W29498910381 @default.
- W2949891038 hasRelatedWork W2006720586 @default.