FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949891844> ?p ?o ?g. }

• W2949891844 abstract "SUMMARY Background: Advances in DNA sequencing have made gene testing fast and affordable, but adaptation of clinical services to capitalise on this for patient benefit has been slow. Ovarian cancer exemplifies limitations of current systems and potential benefits of increased gene testing. Approximately 15% of ovarian cancer patients have a germline mutation in BRCA1 or BRCA2 (collectively termed ‘BRCA’) and this has substantial implications for their personal management and that of their relatives. However, in most countries implementation of BRCA testing in ovarian cancer has been inconsistent and largely unsuccessful. Methods: We developed a mainstream pathway in which BRCA testing was undertaken by cancer team members after 30 minutes online training. Patients with a mutation were sent a genetic appointment with their results. Cascade testing to relatives was performed via standard clinical genetic procedures. Findings: 207 women with ovarian cancer were offered gene testing through the mainstream pathway and all accepted. 33 (16%) had a BRCA mutation. The result informed management of 79% (121/154) women with active disease including 97% (32/33) women with a mutation. All mutation-positive women and ~3.5 relatives per family have been seen in genetics. Patient and clinician feedback was very positive. >95% found the pathway to be simple and effective. The pathway offers considerable reduction in time (~5-fold) and resource requirements (~13-fold) compared to the traditional genetic pathway. We estimate it would deliver £2.6M NHS cost savings per year, and would allow implementation of national testing recommendations with existing infrastructure. Interpretation: Mainstream genetic testing is effective, efficient and patient-centred and offers a mechanism for large-scale implementation of BRCA gene testing in cancer patients. The principles could be applied in many other countries and to many other areas of genomic medicine." @default.
• W2949891844 created "2019-06-27" @default.
• W2949891844 creator A5007424793 @default.
• W2949891844 creator A5011806725 @default.
• W2949891844 creator A5011857990 @default.
• W2949891844 creator A5012825265 @default.
• W2949891844 creator A5015131657 @default.
• W2949891844 creator A5016573665 @default.
• W2949891844 creator A5042521297 @default.
• W2949891844 creator A5054096119 @default.
• W2949891844 creator A5063293745 @default.
• W2949891844 creator A5065447416 @default.
• W2949891844 creator A5074713165 @default.
• W2949891844 creator A5082610858 @default.
• W2949891844 creator A5083547072 @default.
• W2949891844 creator A5089453029 @default.
• W2949891844 date "2016-03-16" @default.
• W2949891844 modified "2023-10-17" @default.
• W2949891844 title "Implementing rapid, robust, cost-effective, patient-centred, routine genetic testing in ovarian cancer patients" @default.
• W2949891844 cites W1484356204 @default.
• W2949891844 cites W1501672857 @default.
• W2949891844 cites W1588157222 @default.
• W2949891844 cites W1748709546 @default.
• W2949891844 cites W1757407923 @default.
• W2949891844 cites W1971954823 @default.
• W2949891844 cites W1972869110 @default.
• W2949891844 cites W1980713899 @default.
• W2949891844 cites W1989949458 @default.
• W2949891844 cites W2002419036 @default.
• W2949891844 cites W2005463423 @default.
• W2949891844 cites W2011830133 @default.
• W2949891844 cites W2044048655 @default.
• W2949891844 cites W2067560254 @default.
• W2949891844 cites W2077915090 @default.
• W2949891844 cites W2083897064 @default.
• W2949891844 cites W2085880302 @default.
• W2949891844 cites W2098633524 @default.
• W2949891844 cites W2099000973 @default.
• W2949891844 cites W2106951948 @default.
• W2949891844 cites W2111488265 @default.
• W2949891844 cites W2116186978 @default.
• W2949891844 cites W2125120881 @default.
• W2949891844 cites W2126170418 @default.
• W2949891844 cites W2130078242 @default.
• W2949891844 cites W2135525536 @default.
• W2949891844 cites W2140563000 @default.
• W2949891844 cites W2140940566 @default.
• W2949891844 cites W2150111967 @default.
• W2949891844 cites W2152217620 @default.
• W2949891844 cites W2169862738 @default.
• W2949891844 cites W2170859535 @default.
• W2949891844 cites W2289386828 @default.
• W2949891844 cites W754073086 @default.
• W2949891844 doi "https://doi.org/10.1101/044024" @default.
• W2949891844 hasPublicationYear "2016" @default.
• W2949891844 type Work @default.
• W2949891844 sameAs 2949891844 @default.
• W2949891844 citedByCount "0" @default.
• W2949891844 crossrefType "posted-content" @default.
• W2949891844 hasAuthorship W2949891844A5007424793 @default.
• W2949891844 hasAuthorship W2949891844A5011806725 @default.
• W2949891844 hasAuthorship W2949891844A5011857990 @default.
• W2949891844 hasAuthorship W2949891844A5012825265 @default.
• W2949891844 hasAuthorship W2949891844A5015131657 @default.
• W2949891844 hasAuthorship W2949891844A5016573665 @default.
• W2949891844 hasAuthorship W2949891844A5042521297 @default.
• W2949891844 hasAuthorship W2949891844A5054096119 @default.
• W2949891844 hasAuthorship W2949891844A5063293745 @default.
• W2949891844 hasAuthorship W2949891844A5065447416 @default.
• W2949891844 hasAuthorship W2949891844A5074713165 @default.
• W2949891844 hasAuthorship W2949891844A5082610858 @default.
• W2949891844 hasAuthorship W2949891844A5083547072 @default.
• W2949891844 hasAuthorship W2949891844A5089453029 @default.
• W2949891844 hasBestOaLocation W29498918441 @default.
• W2949891844 hasConcept C104317684 @default.
• W2949891844 hasConcept C121608353 @default.
• W2949891844 hasConcept C126322002 @default.
• W2949891844 hasConcept C13514818 @default.
• W2949891844 hasConcept C143998085 @default.
• W2949891844 hasConcept C2780194787 @default.
• W2949891844 hasConcept C2780427987 @default.
• W2949891844 hasConcept C2780673598 @default.
• W2949891844 hasConcept C29456083 @default.
• W2949891844 hasConcept C501734568 @default.
• W2949891844 hasConcept C54355233 @default.
• W2949891844 hasConcept C60644358 @default.
• W2949891844 hasConcept C71924100 @default.
• W2949891844 hasConcept C80227256 @default.
• W2949891844 hasConcept C86803240 @default.
• W2949891844 hasConceptScore W2949891844C104317684 @default.
• W2949891844 hasConceptScore W2949891844C121608353 @default.
• W2949891844 hasConceptScore W2949891844C126322002 @default.
• W2949891844 hasConceptScore W2949891844C13514818 @default.
• W2949891844 hasConceptScore W2949891844C143998085 @default.
• W2949891844 hasConceptScore W2949891844C2780194787 @default.
• W2949891844 hasConceptScore W2949891844C2780427987 @default.
• W2949891844 hasConceptScore W2949891844C2780673598 @default.
• W2949891844 hasConceptScore W2949891844C29456083 @default.
• W2949891844 hasConceptScore W2949891844C501734568 @default.
• W2949891844 hasConceptScore W2949891844C54355233 @default.

• next