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- W2949904237 abstract "Lumen integrity in vascularization requires fully differentiated endothelial cells (ECs). Here, we report that endothelial-mesenchymal transitions (EndMTs) emerged in ECs of cerebral arteriovenous malformation (AVMs) and caused disruption of the lumen or lumen disorder. We show that excessive Sry-box 2 (Sox2) signaling was responsible for the EndMTs in cerebral AVMs. EC-specific suppression of Sox2 normalized endothelial differentiation and lumen formation and improved the cerebral AVMs. Epigenetic studies showed that induction of Sox2 altered the cerebral-endothelial transcriptional landscape and identified jumonji domain-containing protein 5 (JMJD5) as a direct target of Sox2. Sox2 interacted with JMJD5 to induce EndMTs in cerebral ECs. Furthermore, we utilized a high-throughput system to identify the β-adrenergic antagonist pronethalol as an inhibitor of Sox2 expression. Treatment with pronethalol stabilized endothelial differentiation and lumen formation, which limited the cerebral AVMs." @default.
- W2949904237 created "2019-06-27" @default.
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- W2949904237 date "2019-06-24" @default.
- W2949904237 modified "2023-10-15" @default.
- W2949904237 title "Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations" @default.
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- W2949904237 cites W1975522586 @default.
- W2949904237 cites W1975746577 @default.
- W2949904237 cites W1982639675 @default.
- W2949904237 cites W1983322974 @default.
- W2949904237 cites W1984720051 @default.
- W2949904237 cites W1991382572 @default.
- W2949904237 cites W1994465939 @default.
- W2949904237 cites W2001364270 @default.
- W2949904237 cites W2002486761 @default.
- W2949904237 cites W2002702165 @default.
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- W2949904237 cites W2012753522 @default.
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- W2949904237 cites W2022090382 @default.
- W2949904237 cites W2026066037 @default.
- W2949904237 cites W2028980592 @default.
- W2949904237 cites W2029372290 @default.
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- W2949904237 doi "https://doi.org/10.1172/jci125965" @default.
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