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- W2949923699 abstract "Epiartemisinin (7) was prepared by the base epimerization of artemisinin (1) and its structure determined by X-ray analysis. The antimalarial activity of 7 against the chloroquine-sensitive and resistant strains of Plasmodium berghei and P. yoelii in the mouse was compared with that of the highly effective schizonticide 1 and found to be drastically diminished. It is argued that the mode of action on the intraerythrocytic parasite by 7 is compromised by steric hindrance arising from the α-disposed Me group. In the initial step, intimate complexation with heme is hindered or biased to favor the formation of a less potent C-centered radical, the final lethal agent." @default.
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- W2949923699 date "2000-06-07" @default.
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- W2949923699 doi "https://doi.org/10.1002/1522-2675(20000607)83:6<1239::aid-hlca1239>3.0.co;2-s" @default.
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