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- W2949948321 endingPage "88" @default.
- W2949948321 startingPage "65" @default.
- W2949948321 abstract "While considerable progress has been made in our understanding of how the brain regulates sleep and wakefulness, including the transitions between sleep and wakefulness, important knowledge gaps persist. In this chapter, we review the experimental work undertaken by scientist over the past 100 years that has informed our modern-day understanding of sleep-wake neurobiology. We now know, for example, that sleep and wake are actively regulated processes and that they are subserved by discrete cell populations, circuit pathways, and transmitters, which we discuss herein. A particularly prominent role for the brain's fast neurotransmitters, glutamate and GABA, in the regulation of wake and sleep has recently emerged, in turn informing the revision of long-standing models of the neurochemical basis of wake and sleep. It is expected that newer and more efficacious drugs for treating disorders of sleep and arousal will be one important product of our revised understanding of the neurochemical milieu of sleep-wake. Perhaps most importantly, however, the experimental work directed at the “how” of sleep and wake has provided several important clues as to the “why” of sleep, which is widely considered to be one of the greatest mysteries in the neurosciences." @default.
- W2949948321 created "2019-06-27" @default.
- W2949948321 creator A5026809730 @default.
- W2949948321 creator A5055163801 @default.
- W2949948321 date "2019-01-01" @default.
- W2949948321 modified "2023-10-15" @default.
- W2949948321 title "The Circuit, Cellular, and Synaptic Bases of Sleep-Wake Regulation" @default.
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