FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949965912> ?p ?o ?g. }

• W2949965912 endingPage "193" @default.
• W2949965912 startingPage "185" @default.
• W2949965912 abstract "Papillary thyroid cancer (PTC) may behave differently in prepubertal children as compared to pubertal children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate the clinicopathological characteristics of PTC patients with emphasis on the pubertal status and also to investigate the association of BRAFV600E mutation with disease characteristics.The medical records of 75 patients with PTC were reviewed retrospectively. BRAFV600E mutation status was available only in the medical records of 56 patients.Mean age at diagnosis was 12.4±3.8 years. There was no difference in sex, initial signs, tumor histopathology, and pathological evidence of tumor aggressiveness between prepubertal and pubertal children. Although not statistically significant, lateral neck nodal metastasis and lung metastasis at diagnosis were more prevalent in prepubertal children. After excluding patients with microcarcinoma, prepubertal children were found to require lateral neck dissection and further doses of radioactive iodine more frequently than pubertal patients. Recurrence was also more frequent in prepubertal children (p=0.016). Frequency of BRAFV600E mutation was similar in prepubertal and pubertal patients. BRAFV600E mutation was found in 14/56 (25%) patients and was high in the classic variant PTC (p=0.004). Multicentricity was high in BRAFV600E mutation (p=0.01). There was no relation between BRAFV600E mutation and lymph node and pulmonary metastasis at diagnosis, or between BRAFV600E mutation and pathological evidence of tumor aggressiveness.PTC is more disseminated in prepubertal children. BRAFV600E mutation does not correlate with a more extensive or aggressive disease. BRAFV600E mutation is not the cause of the differences in the biological behavior of PTC in prepubertal and pubertal children." @default.
• W2949965912 created "2019-06-27" @default.
• W2949965912 creator A5001673819 @default.
• W2949965912 creator A5006325338 @default.
• W2949965912 creator A5016238855 @default.
• W2949965912 creator A5022582838 @default.
• W2949965912 creator A5058515060 @default.
• W2949965912 creator A5073501348 @default.
• W2949965912 date "2017-09-01" @default.
• W2949965912 modified "2023-09-27" @default.
• W2949965912 title "Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation" @default.
• W2949965912 cites W1538981488 @default.
• W2949965912 cites W1568309827 @default.
• W2949965912 cites W1679065037 @default.
• W2949965912 cites W1720744388 @default.
• W2949965912 cites W1927033361 @default.
• W2949965912 cites W1933537883 @default.
• W2949965912 cites W1941653842 @default.
• W2949965912 cites W1979356717 @default.
• W2949965912 cites W1982230475 @default.
• W2949965912 cites W1990713861 @default.
• W2949965912 cites W2001206565 @default.
• W2949965912 cites W2019481551 @default.
• W2949965912 cites W2023325202 @default.
• W2949965912 cites W2025370928 @default.
• W2949965912 cites W2037871574 @default.
• W2949965912 cites W2040165720 @default.
• W2949965912 cites W2045564720 @default.
• W2949965912 cites W2046818976 @default.
• W2949965912 cites W2058009033 @default.
• W2949965912 cites W2061859116 @default.
• W2949965912 cites W2063378987 @default.
• W2949965912 cites W2071628034 @default.
• W2949965912 cites W2075158341 @default.
• W2949965912 cites W2086357335 @default.
• W2949965912 cites W2099982919 @default.
• W2949965912 cites W2101888941 @default.
• W2949965912 cites W2105132224 @default.
• W2949965912 cites W2111052332 @default.
• W2949965912 cites W2118986295 @default.
• W2949965912 cites W2132743439 @default.
• W2949965912 cites W2139518879 @default.
• W2949965912 cites W2143002495 @default.
• W2949965912 cites W2161209070 @default.
• W2949965912 cites W2163455037 @default.
• W2949965912 cites W2163536945 @default.
• W2949965912 cites W2168449521 @default.
• W2949965912 cites W2297375919 @default.
• W2949965912 cites W2314815360 @default.
• W2949965912 doi "https://doi.org/10.4274/jcrpe.3873" @default.
• W2949965912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5596798" @default.
• W2949965912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28077340" @default.
• W2949965912 hasPublicationYear "2017" @default.
• W2949965912 type Work @default.
• W2949965912 sameAs 2949965912 @default.
• W2949965912 citedByCount "14" @default.
• W2949965912 countsByYear W29499659122018 @default.
• W2949965912 countsByYear W29499659122020 @default.
• W2949965912 countsByYear W29499659122021 @default.
• W2949965912 countsByYear W29499659122022 @default.
• W2949965912 countsByYear W29499659122023 @default.
• W2949965912 crossrefType "journal-article" @default.
• W2949965912 hasAuthorship W2949965912A5001673819 @default.
• W2949965912 hasAuthorship W2949965912A5006325338 @default.
• W2949965912 hasAuthorship W2949965912A5016238855 @default.
• W2949965912 hasAuthorship W2949965912A5022582838 @default.
• W2949965912 hasAuthorship W2949965912A5058515060 @default.
• W2949965912 hasAuthorship W2949965912A5073501348 @default.
• W2949965912 hasBestOaLocation W29499659121 @default.
• W2949965912 hasConcept C104317684 @default.
• W2949965912 hasConcept C121608353 @default.
• W2949965912 hasConcept C126322002 @default.
• W2949965912 hasConcept C142724271 @default.
• W2949965912 hasConcept C143998085 @default.
• W2949965912 hasConcept C207886595 @default.
• W2949965912 hasConcept C2779013556 @default.
• W2949965912 hasConcept C2779134260 @default.
• W2949965912 hasConcept C2779761222 @default.
• W2949965912 hasConcept C2781461381 @default.
• W2949965912 hasConcept C501734568 @default.
• W2949965912 hasConcept C526584372 @default.
• W2949965912 hasConcept C54355233 @default.
• W2949965912 hasConcept C544855455 @default.
• W2949965912 hasConcept C71924100 @default.
• W2949965912 hasConcept C86803240 @default.
• W2949965912 hasConcept C90924648 @default.
• W2949965912 hasConceptScore W2949965912C104317684 @default.
• W2949965912 hasConceptScore W2949965912C121608353 @default.
• W2949965912 hasConceptScore W2949965912C126322002 @default.
• W2949965912 hasConceptScore W2949965912C142724271 @default.
• W2949965912 hasConceptScore W2949965912C143998085 @default.
• W2949965912 hasConceptScore W2949965912C207886595 @default.
• W2949965912 hasConceptScore W2949965912C2779013556 @default.
• W2949965912 hasConceptScore W2949965912C2779134260 @default.
• W2949965912 hasConceptScore W2949965912C2779761222 @default.
• W2949965912 hasConceptScore W2949965912C2781461381 @default.
• W2949965912 hasConceptScore W2949965912C501734568 @default.
• W2949965912 hasConceptScore W2949965912C526584372 @default.

• next