FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949968270> ?p ?o ?g. }

• W2949968270 abstract "Biosurfactants are naturally occurring surface active compounds with unique properties such as biodegradability, low toxicity and tolerance to extreme conditions. These unique properties promote their use as alternatives to traditional petrochemical and oleochemical surfactants, as they satisfy requirements for environmentally friendly manufacturing processes. However, the cost of biosurfactants is still significantly higher than chemical surfactants which hinders their large-scale commercialisation. This work presents an investigation into the production of surfactin, a lipopeptide biosurfactant, exploiting its foamability characteristics for the design and implementation of a recirculating continuous foam fractionation column operated in parallel with a bioreactor. Surfactin is a powerful amphiphilic compound produced by Bacillus subtilis. It is a plant-elicitor with antimicrobial properties offering a huge potential in the food and agricultural industries. However, surfactin has extreme foamability even at low concentrations. This foamability can lead to production problems such as large volumes of uncontrolled overflowing foam with significant product and biomass losses. Here, it is demonstrated that this overflow can be controlled, or eliminated, by integrating a foam fractionation system to the bioreactor in a recirculating loop.A dual production and separation process was engineered and enabled reaching high surfactin productivity in a controlled manner. After elucidating the surface properties of surfactin-rich broth, a foam fractionation column was designed for bench-scale production. Operation of the recirculating column in parallel with the bioreactor enabled air flow to be independently controlled for each unit. Surfactin solutions of various concentrations were tested to relate foamability to concentration over a range of bubble sizes. The sintered glass pore size was revealed to be the main factor influencing the enrichment, with a positive correlation with increasing pore size. Characterisation of the fermentation production rate enabled fractionation column air flow rate to be controlled to ensure sufficient foam surface area for product adsorption. The airflow rate was identified as the main factor impacting on the surfactin recovery rate. This characterisation enabled broth feed flow rate to be controlled to balance the removal rate with the production rate. Two processes were created coupling the newly designed fractionation column with the bioreactor operated either in aerated or non-aerated conditions. Under aerated settings, controlled surfactin production was successfully achieved at a productivity of 0.0019 g L-1 h-1 whilst simultaneously recovering 91% of the product at a maximum enrichment of 79 and 116 through the column and overflow routes, respectively. Under non-aerated settings, overflowing foam was fully avoided and 90% of the product was recovered solely through the fractionation column at an enrichment ratio of 40 under non-optimised settings. Additionally, up to 14% (g/g) increase in surfactin production was observed with the coupling of the fractionation column demonstrating a further benefit as a bioprocess intensifying device for surfactin production. This work provides a benchmark for a robust system for surfactin production, substantially improving the productivity at bench scale, potentially leading the way to more productive and less costly industrial processes for surface active compounds in a wide range of industrials fields." @default.
• W2949968270 created "2019-06-27" @default.
• W2949968270 creator A5069917745 @default.
• W2949968270 date "2017-10-03" @default.
• W2949968270 modified "2023-09-27" @default.
• W2949968270 title "Bioprocess intensification of surfactin production" @default.
• W2949968270 cites W1502016351 @default.
• W2949968270 cites W1506253660 @default.
• W2949968270 cites W1515668124 @default.
• W2949968270 cites W1531654029 @default.
• W2949968270 cites W1546783991 @default.
• W2949968270 cites W1581154118 @default.
• W2949968270 cites W1752724830 @default.
• W2949968270 cites W1794431878 @default.
• W2949968270 cites W1844865274 @default.
• W2949968270 cites W195040255 @default.
• W2949968270 cites W1964902015 @default.
• W2949968270 cites W1965306364 @default.
• W2949968270 cites W1967443566 @default.
• W2949968270 cites W1970273570 @default.
• W2949968270 cites W1970805130 @default.
• W2949968270 cites W1970994211 @default.
• W2949968270 cites W1971065175 @default.
• W2949968270 cites W1973451490 @default.
• W2949968270 cites W1974387248 @default.
• W2949968270 cites W1975246690 @default.
• W2949968270 cites W1977802438 @default.
• W2949968270 cites W1979399494 @default.
• W2949968270 cites W1979426550 @default.
• W2949968270 cites W1980957099 @default.
• W2949968270 cites W1984977958 @default.
• W2949968270 cites W1985559434 @default.
• W2949968270 cites W1989184925 @default.
• W2949968270 cites W1989233354 @default.
• W2949968270 cites W1989292429 @default.
• W2949968270 cites W1991473363 @default.
• W2949968270 cites W1993917798 @default.
• W2949968270 cites W1995006590 @default.
• W2949968270 cites W1995535725 @default.
• W2949968270 cites W1996839838 @default.
• W2949968270 cites W1997109383 @default.
• W2949968270 cites W1997325165 @default.
• W2949968270 cites W2002059197 @default.
• W2949968270 cites W2003284202 @default.
• W2949968270 cites W2003386166 @default.
• W2949968270 cites W2004411261 @default.
• W2949968270 cites W2005674354 @default.
• W2949968270 cites W2010439695 @default.
• W2949968270 cites W2011016921 @default.
• W2949968270 cites W2012356076 @default.
• W2949968270 cites W2013888980 @default.
• W2949968270 cites W2014122538 @default.
• W2949968270 cites W2017415320 @default.
• W2949968270 cites W2018397105 @default.
• W2949968270 cites W2021341337 @default.
• W2949968270 cites W2021750211 @default.
• W2949968270 cites W2025844510 @default.
• W2949968270 cites W2026362840 @default.
• W2949968270 cites W2027864783 @default.
• W2949968270 cites W2031745168 @default.
• W2949968270 cites W2032393671 @default.
• W2949968270 cites W2033477953 @default.
• W2949968270 cites W2033690305 @default.
• W2949968270 cites W2033873153 @default.
• W2949968270 cites W2035219118 @default.
• W2949968270 cites W2035376768 @default.
• W2949968270 cites W2036268642 @default.
• W2949968270 cites W2037197612 @default.
• W2949968270 cites W2037226150 @default.
• W2949968270 cites W2039096708 @default.
• W2949968270 cites W2044128702 @default.
• W2949968270 cites W2045317794 @default.
• W2949968270 cites W2046815398 @default.
• W2949968270 cites W2047384559 @default.
• W2949968270 cites W2049565907 @default.
• W2949968270 cites W2050517846 @default.
• W2949968270 cites W2050690244 @default.
• W2949968270 cites W2051330990 @default.
• W2949968270 cites W2051800867 @default.
• W2949968270 cites W2054030788 @default.
• W2949968270 cites W2055284544 @default.
• W2949968270 cites W2057442163 @default.
• W2949968270 cites W2057483337 @default.
• W2949968270 cites W2058123643 @default.
• W2949968270 cites W2059327711 @default.
• W2949968270 cites W2060130613 @default.
• W2949968270 cites W2062802484 @default.
• W2949968270 cites W2064030306 @default.
• W2949968270 cites W2065728777 @default.
• W2949968270 cites W2068980036 @default.
• W2949968270 cites W2070577777 @default.
• W2949968270 cites W2071461119 @default.
• W2949968270 cites W2073431842 @default.
• W2949968270 cites W2074413532 @default.
• W2949968270 cites W2075903967 @default.
• W2949968270 cites W2076163247 @default.
• W2949968270 cites W2077202570 @default.
• W2949968270 cites W2078098461 @default.
• W2949968270 cites W2080189311 @default.
• W2949968270 cites W2082111171 @default.

• next