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• W2949968771 abstract "Abstract Background The current standard of care in locally advanced rectal cancer (LARC) is neoadjuvant long-course chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). Surgery is conventionally performed approximately 6–8 weeks after nCRT. This study aimed to determine the effect on outcomes of extending this interval. Methods A systematic search was performed for studies reporting oncological results that compared the classical interval (less than 8 weeks) from the end of nCRT to TME with a minimum 8-week interval in patients with LARC. The primary endpoint was the rate of pathological complete response (pCR). Secondary endpoints were recurrence-free survival, local recurrence and distant metastasis rates, R0 resection rates, completeness of TME, margin positivity, sphincter preservation, stoma formation, anastomotic leak and other complications. A meta-analysis was performed using the Mantel–Haenszel method. Results Twenty-six publications, including four RCTs, with 25 445 patients were identified. A minimum 8-week interval was associated with increased odds of pCR (odds ratio (OR) 1·41, 95 per cent c.i. 1·30 to 1·52; P &lt; 0·001) and tumour downstaging (OR 1·18, 1·05 to 1·32; P = 0·004). R0 resection rates, TME completeness, lymph node yield, sphincter preservation, stoma formation and complication rates were similar between the two groups. The increased rate of pCR translated to reduced distant metastasis (OR 0·71, 0·54 to 0·93; P = 0·01) and overall recurrence (OR 0·76, 0·58 to 0·98; P = 0·04), but not local recurrence (OR 0·83, 0·49 to 1·42; P = 0·50). Conclusion A minimum 8-week interval from the end of nCRT to TME increases pCR and downstaging rates, and improves recurrence-free survival without compromising surgical morbidity." @default.
• W2949968771 created "2019-06-27" @default.
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• W2949968771 date "2019-06-19" @default.
• W2949968771 modified "2023-10-11" @default.
• W2949968771 title "Meta-analysis of the effect of extending the interval after long-course chemoradiotherapy before surgery in locally advanced rectal cancer" @default.
• W2949968771 cites W1537972189 @default.
• W2949968771 cites W1592964109 @default.
• W2949968771 cites W1826055758 @default.
• W2949968771 cites W1908675343 @default.
• W2949968771 cites W1911303594 @default.
• W2949968771 cites W1943338723 @default.
• W2949968771 cites W1971142314 @default.
• W2949968771 cites W1976176418 @default.
• W2949968771 cites W1978546169 @default.
• W2949968771 cites W1979238043 @default.
• W2949968771 cites W1979423827 @default.
• W2949968771 cites W1981501248 @default.
• W2949968771 cites W1986215651 @default.
• W2949968771 cites W1986872867 @default.
• W2949968771 cites W2005023050 @default.
• W2949968771 cites W2007296899 @default.
• W2949968771 cites W2008992215 @default.
• W2949968771 cites W2017233105 @default.
• W2949968771 cites W2020659765 @default.
• W2949968771 cites W2028945958 @default.
• W2949968771 cites W2031866566 @default.
• W2949968771 cites W2036069859 @default.
• W2949968771 cites W2038068836 @default.
• W2949968771 cites W2039556095 @default.
• W2949968771 cites W2057901226 @default.
• W2949968771 cites W2068898596 @default.
• W2949968771 cites W2073631512 @default.
• W2949968771 cites W2076101066 @default.
• W2949968771 cites W2080875201 @default.
• W2949968771 cites W2086848394 @default.
• W2949968771 cites W2095439981 @default.
• W2949968771 cites W2096998881 @default.
• W2949968771 cites W2101719692 @default.
• W2949968771 cites W2107658298 @default.
• W2949968771 cites W2108051921 @default.
• W2949968771 cites W2108148539 @default.
• W2949968771 cites W2111510200 @default.
• W2949968771 cites W2118983280 @default.
• W2949968771 cites W2122068576 @default.
• W2949968771 cites W2123377696 @default.
• W2949968771 cites W2123432691 @default.
• W2949968771 cites W2123712900 @default.
• W2949968771 cites W2125452425 @default.
• W2949968771 cites W2127326400 @default.
• W2949968771 cites W2138403078 @default.
• W2949968771 cites W2138728054 @default.
• W2949968771 cites W2143847499 @default.
• W2949968771 cites W2144717403 @default.
• W2949968771 cites W2145301587 @default.
• W2949968771 cites W2147475401 @default.
• W2949968771 cites W2156098321 @default.
• W2949968771 cites W2161523093 @default.
• W2949968771 cites W2162617501 @default.
• W2949968771 cites W2252995575 @default.
• W2949968771 cites W2310809385 @default.
• W2949968771 cites W2332439395 @default.
• W2949968771 cites W2339079790 @default.
• W2949968771 cites W2415093419 @default.
• W2949968771 cites W2431692338 @default.
• W2949968771 cites W2492547438 @default.
• W2949968771 cites W2492618519 @default.
• W2949968771 cites W2518860853 @default.
• W2949968771 cites W2521490912 @default.
• W2949968771 cites W2521578090 @default.
• W2949968771 cites W2560171039 @default.
• W2949968771 cites W2586403573 @default.
• W2949968771 cites W2588058127 @default.
• W2949968771 cites W2596096342 @default.
• W2949968771 cites W2761662440 @default.
• W2949968771 cites W2766506046 @default.
• W2949968771 cites W2768704525 @default.
• W2949968771 cites W2809278331 @default.
• W2949968771 cites W2889379497 @default.
• W2949968771 cites W2898705499 @default.
• W2949968771 cites W2991792334 @default.
• W2949968771 doi "https://doi.org/10.1002/bjs.11220" @default.
• W2949968771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31216064" @default.
• W2949968771 hasPublicationYear "2019" @default.
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