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- W2949970462 abstract "A practical synthesis of the dual-action cephalosporin 5 from 7-aminocephalosporanic acid (7-ACA), S-benzothiazol-2-yl (2-amino-4-thiazolyl)(methoxyimino)thioacetate (MAEM), and fleroxacin [6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)- 4-oxo-3-quinolinecarboxylic acid, 3] is described. Tritylated MAEM prepared in situ was coupled with 7-ACA in dichloromethane followed by hydrolysis of the acetate group to afford the 3-hydroxymethyl-3-cephem 2" @default.
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- W2949970462 date "1992-01-01" @default.
- W2949970462 modified "2023-09-26" @default.
- W2949970462 title "Synthesis of a Dual-Action Cephalosporin: A Novel Approach to 3-Acyloxymethyl-3- cephems" @default.
- W2949970462 doi "https://doi.org/10.1055/s-1992-26326" @default.
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