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- W2949972610 endingPage "126" @default.
- W2949972610 startingPage "83" @default.
- W2949972610 abstract "Several first-line chemotherapeutic agents, including taxanes, platinum agents and proteasome inhibitors, are associated with the dose-limiting side effect of chemotherapy-induced peripheral neuropathy (CIPN). CIPN predominantly manifests as sensory symptoms, which are likely due to drug accumulation within peripheral nervous tissues rather than the central nervous system. No treatment is currently available to prevent or reverse CIPN. The causal mechanisms underlying CIPN are not yet fully understood. Mitochondrial dysfunction has emerged as a major factor contributing to the development and maintenance of CIPN. This chapter will provide an overview of both clinical and preclinical data supporting this hypothesis. We will review the studies reporting the nature of mitochondrial dysfunction evoked by chemotherapy in terms of changes in mitochondrial morphology, bioenergetics and reactive oxygen species (ROS) generation. Furthermore, we will discuss the in vivo effects of pharmacological interventions that counteract chemotherapy-evoked mitochondrial dysfunction and ameliorate pain-like behavior." @default.
- W2949972610 created "2019-06-27" @default.
- W2949972610 creator A5073453763 @default.
- W2949972610 creator A5087281051 @default.
- W2949972610 date "2019-01-01" @default.
- W2949972610 modified "2023-10-14" @default.
- W2949972610 title "Mitochondrial dysfunction in the pathogenesis of chemotherapy-induced peripheral neuropathy" @default.
- W2949972610 cites W1519813906 @default.
- W2949972610 cites W1722494167 @default.
- W2949972610 cites W1832113570 @default.
- W2949972610 cites W1966923542 @default.
- W2949972610 cites W1969850018 @default.
- W2949972610 cites W1969902527 @default.
- W2949972610 cites W1971045589 @default.
- W2949972610 cites W1974542461 @default.
- W2949972610 cites W1975519000 @default.
- W2949972610 cites W1978450665 @default.
- W2949972610 cites W1978903047 @default.
- W2949972610 cites W1981182220 @default.
- W2949972610 cites W1981268708 @default.
- W2949972610 cites W1983107467 @default.
- W2949972610 cites W1984608768 @default.
- W2949972610 cites W1994427512 @default.
- W2949972610 cites W1995300665 @default.
- W2949972610 cites W1997440309 @default.
- W2949972610 cites W2002418060 @default.
- W2949972610 cites W2005327851 @default.
- W2949972610 cites W2010677439 @default.
- W2949972610 cites W2017976511 @default.
- W2949972610 cites W2019079031 @default.
- W2949972610 cites W2025968906 @default.
- W2949972610 cites W2032170666 @default.
- W2949972610 cites W2034298930 @default.
- W2949972610 cites W2037439350 @default.
- W2949972610 cites W2037524923 @default.
- W2949972610 cites W2045410360 @default.
- W2949972610 cites W2046374080 @default.
- W2949972610 cites W2047384875 @default.
- W2949972610 cites W2047955445 @default.
- W2949972610 cites W2048580070 @default.
- W2949972610 cites W2048739847 @default.
- W2949972610 cites W2049128074 @default.
- W2949972610 cites W2049213018 @default.
- W2949972610 cites W2049843692 @default.
- W2949972610 cites W2051661023 @default.
- W2949972610 cites W2055248560 @default.
- W2949972610 cites W2057662279 @default.
- W2949972610 cites W2061261792 @default.
- W2949972610 cites W2063601993 @default.
- W2949972610 cites W2063779563 @default.
- W2949972610 cites W2064044580 @default.
- W2949972610 cites W2064959533 @default.
- W2949972610 cites W2065188509 @default.
- W2949972610 cites W2066494377 @default.
- W2949972610 cites W2067500495 @default.
- W2949972610 cites W2069494381 @default.
- W2949972610 cites W2071601351 @default.
- W2949972610 cites W2072706607 @default.
- W2949972610 cites W2073744130 @default.
- W2949972610 cites W2074754570 @default.
- W2949972610 cites W2079378158 @default.
- W2949972610 cites W2080364854 @default.
- W2949972610 cites W2084192782 @default.
- W2949972610 cites W2089729192 @default.
- W2949972610 cites W2090715929 @default.
- W2949972610 cites W2090907917 @default.
- W2949972610 cites W2090994634 @default.
- W2949972610 cites W2102351114 @default.
- W2949972610 cites W2109637975 @default.
- W2949972610 cites W2114159573 @default.
- W2949972610 cites W2114177795 @default.
- W2949972610 cites W2114458368 @default.
- W2949972610 cites W2117515508 @default.
- W2949972610 cites W2118674385 @default.
- W2949972610 cites W2126275851 @default.
- W2949972610 cites W2139521477 @default.
- W2949972610 cites W2139559251 @default.
- W2949972610 cites W2142338863 @default.
- W2949972610 cites W2143505819 @default.
- W2949972610 cites W2144118779 @default.
- W2949972610 cites W2147086910 @default.
- W2949972610 cites W2148454282 @default.
- W2949972610 cites W2149603226 @default.
- W2949972610 cites W2150112288 @default.
- W2949972610 cites W2154578159 @default.
- W2949972610 cites W2156409369 @default.
- W2949972610 cites W2158747145 @default.
- W2949972610 cites W2163024772 @default.
- W2949972610 cites W2163679078 @default.
- W2949972610 cites W2164382965 @default.
- W2949972610 cites W2168407454 @default.
- W2949972610 cites W2191313447 @default.
- W2949972610 cites W2236497497 @default.
- W2949972610 cites W2270968470 @default.
- W2949972610 cites W2280920407 @default.
- W2949972610 cites W2339230698 @default.
- W2949972610 cites W2344203686 @default.
- W2949972610 cites W2431948186 @default.