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- W2950018671 abstract "Abstract A series of rhodanine compounds containing various substituents at the N3- and C5-positions were synthesized and their in vitro activity against a panel of clinically relevant MRSA strains was determined. The anti-MRSA activity of compounds 21 (MIC = 3.9 μg/mL, MBC = 7.8 μg/mL) and 22 (MIC = 1.95 μg/mL, MBC = 7.8 μg/mL) was significantly greater than that of the lead compounds, 1–3 and reference antibiotics penicillin G (MIC = 31.25 μg/mL) and ciprofloxacin (MIC = 7.8 μg/mL) and comparable to that of vancomycin (MIC = 0.97 μg/mL). Compounds 21 and 22 were found to be bactericidal at only 2–4-fold higher than their MIC concentrations. In addition, their MIC values remained unchanged in the presence or absence of 10% serum. Overall, the results suggest that compounds 21 and 22 may be of potential use in the treatment of MRSA infections." @default.
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- W2950018671 date "2011-03-14" @default.
- W2950018671 modified "2023-09-26" @default.
- W2950018671 title "ChemInform Abstract: The Synthesis of Phenylalanine-Derived C5-Substituted Rhodanines and Their Activity Against Selected Methicillin-Resistant Staphylococcus aureus (MRSA) Strains." @default.
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- W2950018671 doi "https://doi.org/10.1002/chin.201114201" @default.
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