Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950029480> ?p ?o ?g. }
- W2950029480 endingPage "e2006348" @default.
- W2950029480 startingPage "e2006348" @default.
- W2950029480 abstract "While short-read sequencing technology has resulted in a sharp increase in the number of species with genome assemblies, these assemblies are typically highly fragmented. Repeats pose the largest challenge for reference genome assembly, and pericentromeric regions and the repeat-rich Y chromosome are typically ignored from sequencing projects. Here, we assemble the genome of Drosophila miranda using long reads for contig formation, chromatin interaction maps for scaffolding and short reads, and optical mapping and bacterial artificial chromosome (BAC) clone sequencing for consensus validation. Our assembly recovers entire chromosomes and contains large fractions of repetitive DNA, including about 41.5 Mb of pericentromeric and telomeric regions, and >100 Mb of the recently formed highly repetitive neo-Y chromosome. While Y chromosome evolution is typically characterized by global sequence loss and shrinkage, the neo-Y increased in size by almost 3-fold because of the accumulation of repetitive sequences. Our high-quality assembly allows us to reconstruct the chromosomal events that have led to the unusual sex chromosome karyotype in D. miranda, including the independent de novo formation of a pair of sex chromosomes at two distinct time points, or the reversion of a former Y chromosome to an autosome." @default.
- W2950029480 created "2019-06-27" @default.
- W2950029480 creator A5000932897 @default.
- W2950029480 creator A5038603694 @default.
- W2950029480 creator A5061552522 @default.
- W2950029480 creator A5090317453 @default.
- W2950029480 creator A5091175771 @default.
- W2950029480 date "2018-07-30" @default.
- W2950029480 modified "2023-10-06" @default.
- W2950029480 title "De novo assembly of a young Drosophila Y chromosome using single-molecule sequencing and chromatin conformation capture" @default.
- W2950029480 cites W1484347389 @default.
- W2950029480 cites W1494284268 @default.
- W2950029480 cites W1967470558 @default.
- W2950029480 cites W1969931202 @default.
- W2950029480 cites W1982855075 @default.
- W2950029480 cites W1983403167 @default.
- W2950029480 cites W1983642572 @default.
- W2950029480 cites W1990232869 @default.
- W2950029480 cites W2002197756 @default.
- W2950029480 cites W2007856267 @default.
- W2950029480 cites W2009323997 @default.
- W2950029480 cites W2014677321 @default.
- W2950029480 cites W2024754608 @default.
- W2950029480 cites W2026292449 @default.
- W2950029480 cites W2028960428 @default.
- W2950029480 cites W2029078135 @default.
- W2950029480 cites W2038831036 @default.
- W2950029480 cites W2042974585 @default.
- W2950029480 cites W2043480384 @default.
- W2950029480 cites W2057234957 @default.
- W2950029480 cites W2058555694 @default.
- W2950029480 cites W2070982388 @default.
- W2950029480 cites W2071729965 @default.
- W2950029480 cites W2078075583 @default.
- W2950029480 cites W2079137969 @default.
- W2950029480 cites W2087490640 @default.
- W2950029480 cites W2089920619 @default.
- W2950029480 cites W2090037139 @default.
- W2950029480 cites W2095004534 @default.
- W2950029480 cites W2102278945 @default.
- W2950029480 cites W2102283657 @default.
- W2950029480 cites W2102385769 @default.
- W2950029480 cites W2102619694 @default.
- W2950029480 cites W2103441770 @default.
- W2950029480 cites W2104005232 @default.
- W2950029480 cites W2107282968 @default.
- W2950029480 cites W2108234281 @default.
- W2950029480 cites W2108565529 @default.
- W2950029480 cites W2111350087 @default.
- W2950029480 cites W2111913614 @default.
- W2950029480 cites W2112814753 @default.
- W2950029480 cites W2122152054 @default.
- W2950029480 cites W2123785866 @default.
- W2950029480 cites W2128953978 @default.
- W2950029480 cites W2129497695 @default.
- W2950029480 cites W2130131141 @default.
- W2950029480 cites W2141572089 @default.
- W2950029480 cites W2152073175 @default.
- W2950029480 cites W2155150900 @default.
- W2950029480 cites W2155628349 @default.
- W2950029480 cites W2156176296 @default.
- W2950029480 cites W2159093391 @default.
- W2950029480 cites W2160838716 @default.
- W2950029480 cites W2165505716 @default.
- W2950029480 cites W2166252054 @default.
- W2950029480 cites W2170551349 @default.
- W2950029480 cites W2171297609 @default.
- W2950029480 cites W2283634098 @default.
- W2950029480 cites W2300605489 @default.
- W2950029480 cites W2313423684 @default.
- W2950029480 cites W2324342661 @default.
- W2950029480 cites W2331973675 @default.
- W2950029480 cites W2346061920 @default.
- W2950029480 cites W2396077153 @default.
- W2950029480 cites W2479687279 @default.
- W2950029480 cites W2481029670 @default.
- W2950029480 cites W2538143681 @default.
- W2950029480 cites W2545753590 @default.
- W2950029480 cites W2582329608 @default.
- W2950029480 cites W2592985789 @default.
- W2950029480 cites W2594081754 @default.
- W2950029480 cites W2760192776 @default.
- W2950029480 cites W2781979622 @default.
- W2950029480 cites W2790220607 @default.
- W2950029480 cites W2887563444 @default.
- W2950029480 cites W2950354111 @default.
- W2950029480 cites W2950547016 @default.
- W2950029480 cites W2950901140 @default.
- W2950029480 cites W349686162 @default.
- W2950029480 doi "https://doi.org/10.1371/journal.pbio.2006348" @default.
- W2950029480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6117089" @default.
- W2950029480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30059545" @default.
- W2950029480 hasPublicationYear "2018" @default.
- W2950029480 type Work @default.
- W2950029480 sameAs 2950029480 @default.
- W2950029480 citedByCount "82" @default.
- W2950029480 countsByYear W29500294802018 @default.
- W2950029480 countsByYear W29500294802019 @default.