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- W2950030633 abstract "Various new nitrosoureido derivatives of di- or trideoxy sugars were synthesized. The influence of the hydroxyl substitution pattern, the configuration at the anomeric center, and the absolute configuration of the sugar moiety on the antitumor activity of a series of nitrosoureido derivatives of di- and trideoxy sugars was studied. All compounds showed a very significant activity in vivo against L1210 leukemia, B16 melanocarcinoma, and Lewis lung carcinoma. Methyl 3-[3-(2-chloroethyl)-3-nitrosoureido]-2,3-dideoxy-alpha-D-arabino- hexopyranoside, 24 (NSC 609224), was found to be the most active compound. When treated with 24 (NSC 609224) at 20 mg/kg on day 1, at least 90% of the L1210 leukemia and B16 melanocarcinoma bearing mice showed a survival of over 60 days for a LD50 value for this compound of 42 mg/kg." @default.
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- W2950030633 date "1989-06-20" @default.
- W2950030633 modified "2023-09-25" @default.
- W2950030633 title "ChemInform Abstract: Rationale for the Synthesis and Preliminary Biological Evaluation of Highly Active New Antitumor Nitrosoureido Sugars." @default.
- W2950030633 cites W2071695026 @default.
- W2950030633 doi "https://doi.org/10.1002/chin.198925276" @default.
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