FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950032406> ?p ?o ?g. }

• W2950032406 endingPage "109099" @default.
• W2950032406 startingPage "109099" @default.
• W2950032406 abstract "Inflammation and coagulation are two important processes implicated in venous thromboembolism (VTE). 15-epi-lipoxin A4 (15-epi-LXA4) is the epimer of LXA4, a small lipid molecule, is known to play a key role in the resolution of inflammation. This study aimed to demonstrate whether 15-epi-LXA4 could suppress the inflammatory factor tumor necrosis factor-alpha (TNF-α)-induced upregulation of tissue factor (TF), an important regulator of the blood coagulation cascade, and evaluated the possible underlying mechanisms. We found that 15-epi-LXA4 not only reduced the up-regulation of mRNA and antigens, but also lowered the activity of TF (elevated by TNF-α) in primary culture of human umbilical vein endothelial cells (pc-HUVECs). In addition, 15-epi-LXA4 suppressed the activation of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway, induced by TNF-α, in pc-HUVECs. 15-epi-LXA4 also inhibited the binding of NF-κB on the TF promoter, which is otherwise enhanced by TNF-α. The role of 15-epi-LXA4 in regulating TNF-α-induced effects was enhanced by the PI3K inhibitor and prevented by the PI3K activator. In conclusion, 15-epi-LXA4 lowered the TNF-α-induced high TF expression and activity by suppressing PI3K/AKT signaling activation, thereby reducing the binding capacity of NF-κB on the TF promoter in pc-HUVECs." @default.
• W2950032406 created "2019-06-27" @default.
• W2950032406 creator A5010885254 @default.
• W2950032406 creator A5014294067 @default.
• W2950032406 creator A5021809579 @default.
• W2950032406 creator A5022593281 @default.
• W2950032406 creator A5022815401 @default.
• W2950032406 creator A5031012348 @default.
• W2950032406 creator A5054213833 @default.
• W2950032406 creator A5056624305 @default.
• W2950032406 creator A5073226700 @default.
• W2950032406 creator A5087559484 @default.
• W2950032406 creator A5091805745 @default.
• W2950032406 date "2019-09-01" @default.
• W2950032406 modified "2023-10-02" @default.
• W2950032406 title "15-epi-lipoxin A4 inhibits TNF-α-induced tissue factor expression via the PI3K/AKT/ NF-κB axis in human umbilical vein endothelial cells" @default.
• W2950032406 cites W1065629687 @default.
• W2950032406 cites W1832132481 @default.
• W2950032406 cites W1954611773 @default.
• W2950032406 cites W1964440464 @default.
• W2950032406 cites W1967826083 @default.
• W2950032406 cites W1975531685 @default.
• W2950032406 cites W1980831964 @default.
• W2950032406 cites W1983966231 @default.
• W2950032406 cites W1989528047 @default.
• W2950032406 cites W2000653373 @default.
• W2950032406 cites W2000987582 @default.
• W2950032406 cites W2009399552 @default.
• W2950032406 cites W2032955209 @default.
• W2950032406 cites W2035553371 @default.
• W2950032406 cites W2038238165 @default.
• W2950032406 cites W2046986971 @default.
• W2950032406 cites W2051613113 @default.
• W2950032406 cites W2060346337 @default.
• W2950032406 cites W2065276135 @default.
• W2950032406 cites W2075962202 @default.
• W2950032406 cites W2080897456 @default.
• W2950032406 cites W2098714490 @default.
• W2950032406 cites W2099408369 @default.
• W2950032406 cites W2104320125 @default.
• W2950032406 cites W2107277218 @default.
• W2950032406 cites W2113203684 @default.
• W2950032406 cites W2120591360 @default.
• W2950032406 cites W2124342021 @default.
• W2950032406 cites W2134053129 @default.
• W2950032406 cites W2143751549 @default.
• W2950032406 cites W2158356009 @default.
• W2950032406 cites W2205449455 @default.
• W2950032406 cites W2406774866 @default.
• W2950032406 cites W2586901192 @default.
• W2950032406 cites W2622489359 @default.
• W2950032406 cites W2748684526 @default.
• W2950032406 cites W2763116192 @default.
• W2950032406 cites W2782423901 @default.
• W2950032406 cites W2900408032 @default.
• W2950032406 doi "https://doi.org/10.1016/j.biopha.2019.109099" @default.
• W2950032406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31200255" @default.
• W2950032406 hasPublicationYear "2019" @default.
• W2950032406 type Work @default.
• W2950032406 sameAs 2950032406 @default.
• W2950032406 citedByCount "10" @default.
• W2950032406 countsByYear W29500324062019 @default.
• W2950032406 countsByYear W29500324062020 @default.
• W2950032406 countsByYear W29500324062022 @default.
• W2950032406 countsByYear W29500324062023 @default.
• W2950032406 crossrefType "journal-article" @default.
• W2950032406 hasAuthorship W2950032406A5010885254 @default.
• W2950032406 hasAuthorship W2950032406A5014294067 @default.
• W2950032406 hasAuthorship W2950032406A5021809579 @default.
• W2950032406 hasAuthorship W2950032406A5022593281 @default.
• W2950032406 hasAuthorship W2950032406A5022815401 @default.
• W2950032406 hasAuthorship W2950032406A5031012348 @default.
• W2950032406 hasAuthorship W2950032406A5054213833 @default.
• W2950032406 hasAuthorship W2950032406A5056624305 @default.
• W2950032406 hasAuthorship W2950032406A5073226700 @default.
• W2950032406 hasAuthorship W2950032406A5087559484 @default.
• W2950032406 hasAuthorship W2950032406A5091805745 @default.
• W2950032406 hasBestOaLocation W29500324061 @default.
• W2950032406 hasConcept C126322002 @default.
• W2950032406 hasConcept C134018914 @default.
• W2950032406 hasConcept C17991360 @default.
• W2950032406 hasConcept C185592680 @default.
• W2950032406 hasConcept C186738567 @default.
• W2950032406 hasConcept C202751555 @default.
• W2950032406 hasConcept C203014093 @default.
• W2950032406 hasConcept C2776914184 @default.
• W2950032406 hasConcept C2777411675 @default.
• W2950032406 hasConcept C2777730290 @default.
• W2950032406 hasConcept C2778382381 @default.
• W2950032406 hasConcept C55493867 @default.
• W2950032406 hasConcept C62478195 @default.
• W2950032406 hasConcept C71924100 @default.
• W2950032406 hasConcept C75217442 @default.
• W2950032406 hasConcept C86554907 @default.
• W2950032406 hasConcept C86803240 @default.
• W2950032406 hasConcept C95444343 @default.
• W2950032406 hasConceptScore W2950032406C126322002 @default.
• W2950032406 hasConceptScore W2950032406C134018914 @default.

• next