Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950060974> ?p ?o ?g. }
- W2950060974 endingPage "30" @default.
- W2950060974 startingPage "1" @default.
- W2950060974 abstract "Generally, inflammatory bowel disease (IBD) can be caused by psychology, genes, environment, and gut microbiota. Therefore, IBD therapy should be improved to utilize multiple strategies. Shen Ling Bai Zhu San (SLBZS) adheres to the aim of combating complex diseases from an integrative and holistic perspective, which is effective for IBD therapy. Herein, a systems pharmacology and microbiota approach was developed for these molecular mechanisms exemplified by SLBZS. First, by systematic absorption-distribution-metabolism-excretion (ADME) analysis, potential active compounds and their corresponding direct targets were retrieved. Then, the network relationships among the active compounds, targets, and disease were built to deduce the pharmacological actions of the drug. Finally, an “IBD pathway” consisting of several regulatory modules was proposed to dissect the therapeutic effects of SLBZS. In addition, the effects of SLBZS on gut microbiota were evaluated through analysis of the V3-V4 region and multivariate statistical methods. SLBZS significantly shifted the gut microbiota structure in a rat model. Taken together, we found that SLBZS has multidimensionality in the regulation of IBD-related physiological processes, which provides new sights into herbal medicine for the treatment of IBD." @default.
- W2950060974 created "2019-06-27" @default.
- W2950060974 creator A5008363900 @default.
- W2950060974 creator A5015576422 @default.
- W2950060974 creator A5020141885 @default.
- W2950060974 creator A5063718161 @default.
- W2950060974 creator A5063836862 @default.
- W2950060974 creator A5065858858 @default.
- W2950060974 creator A5069303110 @default.
- W2950060974 creator A5072032484 @default.
- W2950060974 creator A5079117313 @default.
- W2950060974 date "2019-06-23" @default.
- W2950060974 modified "2023-10-18" @default.
- W2950060974 title "Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD" @default.
- W2950060974 cites W1462606079 @default.
- W2950060974 cites W1645427546 @default.
- W2950060974 cites W1685675634 @default.
- W2950060974 cites W1893209424 @default.
- W2950060974 cites W1944754896 @default.
- W2950060974 cites W1974223972 @default.
- W2950060974 cites W1979217507 @default.
- W2950060974 cites W1979656349 @default.
- W2950060974 cites W1980133038 @default.
- W2950060974 cites W1983198554 @default.
- W2950060974 cites W1995393174 @default.
- W2950060974 cites W1997240104 @default.
- W2950060974 cites W1999148058 @default.
- W2950060974 cites W2004608617 @default.
- W2950060974 cites W2005980535 @default.
- W2950060974 cites W2008356343 @default.
- W2950060974 cites W2011596253 @default.
- W2950060974 cites W2018718597 @default.
- W2950060974 cites W2028752026 @default.
- W2950060974 cites W2029665585 @default.
- W2950060974 cites W2033591223 @default.
- W2950060974 cites W2038100201 @default.
- W2950060974 cites W2039006573 @default.
- W2950060974 cites W2047208232 @default.
- W2950060974 cites W2047924033 @default.
- W2950060974 cites W2052834898 @default.
- W2950060974 cites W2059994020 @default.
- W2950060974 cites W2063160102 @default.
- W2950060974 cites W2067951017 @default.
- W2950060974 cites W2070603512 @default.
- W2950060974 cites W2071598106 @default.
- W2950060974 cites W2075678565 @default.
- W2950060974 cites W2084981004 @default.
- W2950060974 cites W2085284704 @default.
- W2950060974 cites W2086030658 @default.
- W2950060974 cites W2086623759 @default.
- W2950060974 cites W2087956925 @default.
- W2950060974 cites W2090821599 @default.
- W2950060974 cites W2096701144 @default.
- W2950060974 cites W2103951757 @default.
- W2950060974 cites W2104871495 @default.
- W2950060974 cites W2108987136 @default.
- W2950060974 cites W2109069677 @default.
- W2950060974 cites W2110235509 @default.
- W2950060974 cites W2110300022 @default.
- W2950060974 cites W2118173539 @default.
- W2950060974 cites W2125744401 @default.
- W2950060974 cites W2131462893 @default.
- W2950060974 cites W2138934663 @default.
- W2950060974 cites W2141474026 @default.
- W2950060974 cites W2148595196 @default.
- W2950060974 cites W2155142785 @default.
- W2950060974 cites W2161088465 @default.
- W2950060974 cites W2165010651 @default.
- W2950060974 cites W2165500432 @default.
- W2950060974 cites W2165593729 @default.
- W2950060974 cites W2169547219 @default.
- W2950060974 cites W2182878044 @default.
- W2950060974 cites W2328023807 @default.
- W2950060974 cites W2343297760 @default.
- W2950060974 cites W2345810007 @default.
- W2950060974 cites W2396003270 @default.
- W2950060974 cites W2407041001 @default.
- W2950060974 cites W2409656339 @default.
- W2950060974 cites W2472640430 @default.
- W2950060974 cites W2507010070 @default.
- W2950060974 cites W2511020365 @default.
- W2950060974 cites W2515804734 @default.
- W2950060974 cites W2521532521 @default.
- W2950060974 cites W2590308006 @default.
- W2950060974 cites W2608348693 @default.
- W2950060974 cites W2611360243 @default.
- W2950060974 cites W2611721754 @default.
- W2950060974 cites W2613151721 @default.
- W2950060974 cites W2745400272 @default.
- W2950060974 cites W2747595870 @default.
- W2950060974 cites W2762197491 @default.
- W2950060974 cites W2765334581 @default.
- W2950060974 cites W2772220218 @default.
- W2950060974 cites W2775631846 @default.
- W2950060974 cites W2776025116 @default.
- W2950060974 cites W2778360803 @default.
- W2950060974 cites W2786841172 @default.
- W2950060974 cites W2791416031 @default.