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- W2950102364 abstract "Substituted gold(III) tetraarylporphyrins have been synthesised. The analogues TPPAuCl (TPP = tetraphenylporhyrin), MeOTPPAuCl, TMOPPAuCl, MeO 2 CTPPAuCl, O 2 NTPPAuCl and PyTPPAuCl were evaluated for their in vitro cytotoxic activity against the Sarcoma 180 mouse tumour cell line panel. Compound MeO 2 CTPPAuCl exhibited good growth inhibitory properties against Sarcoma 180 and afforded IC 50 values <3μM for 92.386% of the cell lines in the panel. Compounds MeOTPPAuCl and TPPAuCl were effective inhibitors of tumour cell growth, but generally less effective than MeO 2 CTPPAuCl as cytotoxic agents." @default.
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- W2950102364 date "2011-03-01" @default.
- W2950102364 modified "2023-09-24" @default.
- W2950102364 title "Synthesis and Biological Evaluation of Gold(III) Substituted Tetraarylporphyrin Chlorides as Anticancer Reagents" @default.
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- W2950102364 doi "https://doi.org/10.3184/174751911x12992544137142" @default.
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