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- W2950112737 abstract "Abstract The organic extract of the fermentation broth of an unidentified fungus was found to contain three epidermal growth factor (EGF) receptor anagonists: SCH 64874 ( 1 ), SCH 64875 ( 2 ), SCH 64877 ( 3 ). These compounds belong to a family of thiodiketopiperazine derivatives and are esters of an eight carbon aliphatic acid, 2,4- dimethyl-3-hydroxyhexanoic acid and a thiodiketopiperazine, aranotin. They exhibited potent EGF receptor antagonist activity. The IC 50 in EGF receptor assays for compounds 1 , 2 and 3 are 1.0, 1.0 and 1.25 μg/ml, respectively." @default.
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- W2950112737 date "2010-08-03" @default.
- W2950112737 modified "2023-09-25" @default.
- W2950112737 title "ChemInform Abstract: Novel Thiodiketopiperazine Fungal Metabolites as Epidermal Growth Factor Receptor Antagonists." @default.
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- W2950112737 doi "https://doi.org/10.1002/chin.199724223" @default.
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