Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950124496> ?p ?o ?g. }
- W2950124496 endingPage "4191" @default.
- W2950124496 startingPage "4180" @default.
- W2950124496 abstract "White matter microstructure is affected by immune system activity via the actions of circulating pro-inflammatory cytokines. Although white matter microstructure and inflammatory measures are significantly heritable, it is unclear if overlapping genetic factors influence these traits in humans. We conducted genetic correlation analyses of these traits using randomly ascertained extended pedigrees from the Genetics of Brain Structure and Function Study (N = 1862, 59% females, ages 18-97 years; 42 ± 15.7). White matter microstructure was assessed using fractional anisotropy (FA) calculated from diffusion tensor imaging (DTI). Circulating levels (pg/mL) of pro-inflammatory cytokines (IL-6, IL-8, and TNFα) phenotypically associated with white matter microstructure were quantified from blood serum. All traits were significantly heritable (h2 ranging from 0.41 to 0.66 for DTI measures and from 0.18 to 0.30 for inflammatory markers). Phenotypically, higher levels of circulating inflammatory markers were associated with lower FA values across the brain (r = -.03 to r = -.17). There were significant negative genetic correlations between most DTI measures and IL-8 and TNFα, although effects for TNFα were no longer significant when covarying for body mass index. Genetic correlations between DTI measures and IL-6 were not significant. Understanding the genetic correlation between specific inflammatory markers and DTI measures may help researchers focus questions related to inflammatory processes and brain structure." @default.
- W2950124496 created "2019-06-27" @default.
- W2950124496 creator A5001935511 @default.
- W2950124496 creator A5004538115 @default.
- W2950124496 creator A5014310950 @default.
- W2950124496 creator A5017663367 @default.
- W2950124496 creator A5022342401 @default.
- W2950124496 creator A5031109876 @default.
- W2950124496 creator A5033419015 @default.
- W2950124496 creator A5048891768 @default.
- W2950124496 creator A5061513074 @default.
- W2950124496 creator A5063733901 @default.
- W2950124496 creator A5069851068 @default.
- W2950124496 creator A5069869870 @default.
- W2950124496 creator A5074299304 @default.
- W2950124496 creator A5077079758 @default.
- W2950124496 creator A5088365248 @default.
- W2950124496 creator A5091347387 @default.
- W2950124496 date "2019-06-11" @default.
- W2950124496 modified "2023-10-16" @default.
- W2950124496 title "Evidence for genetic correlation between human cerebral white matter microstructure and inflammation" @default.
- W2950124496 cites W1526172542 @default.
- W2950124496 cites W1569693056 @default.
- W2950124496 cites W1855316965 @default.
- W2950124496 cites W1979454503 @default.
- W2950124496 cites W1979881437 @default.
- W2950124496 cites W1984255268 @default.
- W2950124496 cites W1985450416 @default.
- W2950124496 cites W1986049860 @default.
- W2950124496 cites W1988961665 @default.
- W2950124496 cites W1994947322 @default.
- W2950124496 cites W2000557043 @default.
- W2950124496 cites W2003539800 @default.
- W2950124496 cites W2004006028 @default.
- W2950124496 cites W2006096283 @default.
- W2950124496 cites W2009837079 @default.
- W2950124496 cites W2010139869 @default.
- W2950124496 cites W2016876321 @default.
- W2950124496 cites W2038138146 @default.
- W2950124496 cites W2042410266 @default.
- W2950124496 cites W2045353197 @default.
- W2950124496 cites W2046942679 @default.
- W2950124496 cites W2047271888 @default.
- W2950124496 cites W2047829922 @default.
- W2950124496 cites W2051391308 @default.
- W2950124496 cites W2052969270 @default.
- W2950124496 cites W2055264753 @default.
- W2950124496 cites W2055835573 @default.
- W2950124496 cites W2055869800 @default.
- W2950124496 cites W2065123450 @default.
- W2950124496 cites W2065201220 @default.
- W2950124496 cites W2069375519 @default.
- W2950124496 cites W2071881327 @default.
- W2950124496 cites W2073850739 @default.
- W2950124496 cites W2073882423 @default.
- W2950124496 cites W2077314372 @default.
- W2950124496 cites W2079283517 @default.
- W2950124496 cites W2087072867 @default.
- W2950124496 cites W2089565962 @default.
- W2950124496 cites W2089633133 @default.
- W2950124496 cites W2093152647 @default.
- W2950124496 cites W2093222023 @default.
- W2950124496 cites W2110065044 @default.
- W2950124496 cites W2110742166 @default.
- W2950124496 cites W2112488255 @default.
- W2950124496 cites W2113842263 @default.
- W2950124496 cites W2115335486 @default.
- W2950124496 cites W2115762583 @default.
- W2950124496 cites W2120987567 @default.
- W2950124496 cites W2123884323 @default.
- W2950124496 cites W2125978064 @default.
- W2950124496 cites W2127309075 @default.
- W2950124496 cites W2129423257 @default.
- W2950124496 cites W2137104082 @default.
- W2950124496 cites W2143199340 @default.
- W2950124496 cites W2147133578 @default.
- W2950124496 cites W2147881944 @default.
- W2950124496 cites W2150667092 @default.
- W2950124496 cites W2152292563 @default.
- W2950124496 cites W2153263323 @default.
- W2950124496 cites W2154453846 @default.
- W2950124496 cites W2158106656 @default.
- W2950124496 cites W2158978919 @default.
- W2950124496 cites W2160197468 @default.
- W2950124496 cites W2161266571 @default.
- W2950124496 cites W2162039581 @default.
- W2950124496 cites W2162656570 @default.
- W2950124496 cites W2162840291 @default.
- W2950124496 cites W2183959543 @default.
- W2950124496 cites W2254802873 @default.
- W2950124496 cites W2272198956 @default.
- W2950124496 cites W2275987836 @default.
- W2950124496 cites W2307324788 @default.
- W2950124496 cites W2340656051 @default.
- W2950124496 cites W2474093999 @default.
- W2950124496 cites W2500109500 @default.
- W2950124496 cites W2566908060 @default.
- W2950124496 cites W2587680743 @default.