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• W2950144031 startingPage "1351" @default.
• W2950144031 abstract "Studies on the genetics of adaptation typically neglect the possibility that a deleterious mutation might fix. Nonetheless, here we show that, in many regimes, the first substitution is most often deleterious, even when fitness is expected to increase in the long term. In particular, we prove that this phenomenon occurs under weak mutation for any house-of-cards model with an equilibrium distribution. We find that the same qualitative results hold under Fisher's geometric model. We also provide a simple intuition for the surprising prevalence of unconditionally deleterious substitutions during early adaptation. Importantly, the phenomenon we describe occurs on fitness landscapes without any local maxima and is therefore distinct from valley-crossing. Our results imply that the common practice of ignoring deleterious substitutions leads to qualitatively incorrect predictions in many regimes. Our results also have implications for the substitution process at equilibrium and for the response to a sudden decrease in population size." @default.
• W2950144031 created "2019-06-27" @default.
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• W2950144031 date "2014-03-04" @default.
• W2950144031 modified "2023-09-24" @default.
• W2950144031 title "THE INEVITABILITY OF UNCONDITIONALLY DELETERIOUS SUBSTITUTIONS DURING ADAPTATION" @default.
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• W2950144031 doi "https://doi.org/10.1111/evo.12350" @default.
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