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- W2950147472 abstract "Due to acquired resistance or limitations of the currently approved drugs against cancer, there is an urgent need for the development of new classes of compounds. Among others, there is an increasing attention towards the use of Ru(II) polypyridyl complexes. Most studies in the literature were made on complexes based on the coordination of N-donating bidentate ligands to the ruthenium core whereas studies on 2,2′:6′, 2″-terpyridine (terpy) coordinating ligands are relatively scare. However, several studies have shown that [Ru(terpy)2]2+ derivatives are able bind to DNA through various binding modes making these compounds potentially suitable as chemotherapeutic agents. Additionally, light irradiation of these compounds was shown to enable DNA cleavage, highlighting their potential use as photosensitizers (PSs) for photodynamic therapy (PDT). In this work, we present the systematic investigation of the potential of 7 complexes of the type [Ru(terpy)(terpy-X)]2+ (X = H (1), Cl (2), Br (3), OMe (4), COOH (5), COOMe (6), NMe2 (7)) as potential chemotherapeutic agents and PDT PSs. Importantly, six of the seven complexes were found to be stable in human plasma as well as photostable in acetonitrile upon continuous light irradiation (480 nm). The determination of the distribution coefficient logP values for the 7 complexes revealed their good water solubility. Complex 7 was found to be cytotoxic in the micromolar range in the dark as well as to have some phototoxicity upon light exposure at 480 nm in non-cancerous retinal pigment epithelium (RPE-1) and cancerous human cervical carcinoma (HeLa) cells. The systematic investigation of the potential of 7 complexes of the type [Ru(terpy)(terpy-X)]2+ (terpy: 2,2′:6′, 2″-terpyridine; X = H (1), Cl (2), Br (3), OMe (4), COOH (5), COOMe (6), NMe2 (7)) as potential chemotherapeutic agents and photosensitizers for photodynamic therapy is presented." @default.
- W2950147472 created "2019-06-27" @default.
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- W2950147472 date "2019-09-01" @default.
- W2950147472 modified "2023-10-18" @default.
- W2950147472 title "Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes" @default.
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- W2950147472 cites W1974956618 @default.
- W2950147472 cites W1984668192 @default.
- W2950147472 cites W1984987391 @default.
- W2950147472 cites W1990218577 @default.
- W2950147472 cites W1990997378 @default.
- W2950147472 cites W1994172667 @default.
- W2950147472 cites W1994426246 @default.
- W2950147472 cites W1999292430 @default.
- W2950147472 cites W2002885572 @default.
- W2950147472 cites W2009152072 @default.
- W2950147472 cites W2010363805 @default.
- W2950147472 cites W2010544091 @default.
- W2950147472 cites W2020708117 @default.
- W2950147472 cites W2021412675 @default.
- W2950147472 cites W2022967113 @default.
- W2950147472 cites W2023253655 @default.
- W2950147472 cites W2026178009 @default.
- W2950147472 cites W2035752597 @default.
- W2950147472 cites W2041486892 @default.
- W2950147472 cites W2051204775 @default.
- W2950147472 cites W2051345608 @default.
- W2950147472 cites W2053054860 @default.
- W2950147472 cites W2054971145 @default.
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- W2950147472 cites W2058319231 @default.
- W2950147472 cites W2059205366 @default.
- W2950147472 cites W2062058561 @default.
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- W2950147472 cites W2080503518 @default.
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- W2950147472 doi "https://doi.org/10.1016/j.jinorgbio.2019.110752" @default.
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