Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950147893> ?p ?o ?g. }
- W2950147893 abstract "Abstract Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. We have recently identified that NOTCH1 can drive ‘lateral induction’ of a unique senescence phenotype in adjacent cells by specifically upregulating the NOTCH ligand JAG1. Here we show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously. In addition to senescence-associated heterochromatic foci (SAHF), oncogenic RAS-induced senescent (RIS) cells exhibit a massive increase in chromatin accessibility. NOTCH signalling suppresses SAHF and increased chromatin accessibility in this context. Strikingly, NOTCH-induced senescent cells, or cancer cells with high JAG1 expression, drive similar chromatin architectural changes in adjacent cells through cell–cell contact. Mechanistically, we show that NOTCH signalling represses the chromatin architectural protein HMGA1, an association found in multiple human cancers. Thus, HMGA1 is involved not only in SAHFs but also in RIS-driven chromatin accessibility. In conclusion, this study identifies that the JAG1–NOTCH–HMGA1 axis mediates the juxtacrine regulation of chromatin architecture." @default.
- W2950147893 created "2019-06-27" @default.
- W2950147893 creator A5002589388 @default.
- W2950147893 creator A5003961984 @default.
- W2950147893 creator A5013116487 @default.
- W2950147893 creator A5016024868 @default.
- W2950147893 creator A5018384613 @default.
- W2950147893 creator A5021449949 @default.
- W2950147893 creator A5034705836 @default.
- W2950147893 creator A5038755096 @default.
- W2950147893 creator A5040551102 @default.
- W2950147893 creator A5043280248 @default.
- W2950147893 creator A5053276768 @default.
- W2950147893 creator A5066453383 @default.
- W2950147893 creator A5086264006 @default.
- W2950147893 creator A5086973245 @default.
- W2950147893 date "2018-05-09" @default.
- W2950147893 modified "2023-10-16" @default.
- W2950147893 title "NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence" @default.
- W2950147893 cites W1540264737 @default.
- W2950147893 cites W1570622790 @default.
- W2950147893 cites W1923882567 @default.
- W2950147893 cites W1963891946 @default.
- W2950147893 cites W1965124005 @default.
- W2950147893 cites W1967769642 @default.
- W2950147893 cites W1973300568 @default.
- W2950147893 cites W1977709885 @default.
- W2950147893 cites W1984762771 @default.
- W2950147893 cites W1989261729 @default.
- W2950147893 cites W1996203485 @default.
- W2950147893 cites W1997801717 @default.
- W2950147893 cites W2005248738 @default.
- W2950147893 cites W2010417927 @default.
- W2950147893 cites W2012016256 @default.
- W2950147893 cites W2012315992 @default.
- W2950147893 cites W2014677321 @default.
- W2950147893 cites W2016136785 @default.
- W2950147893 cites W2024000011 @default.
- W2950147893 cites W2036897871 @default.
- W2950147893 cites W2043398720 @default.
- W2950147893 cites W2048865995 @default.
- W2950147893 cites W2049315150 @default.
- W2950147893 cites W2057267524 @default.
- W2950147893 cites W2057692691 @default.
- W2950147893 cites W2065557328 @default.
- W2950147893 cites W2070050178 @default.
- W2950147893 cites W2071955851 @default.
- W2950147893 cites W2078281194 @default.
- W2950147893 cites W2078697242 @default.
- W2950147893 cites W2081408710 @default.
- W2950147893 cites W2083953218 @default.
- W2950147893 cites W2088720735 @default.
- W2950147893 cites W2099122564 @default.
- W2950147893 cites W2102619694 @default.
- W2950147893 cites W2103441770 @default.
- W2950147893 cites W2106131814 @default.
- W2950147893 cites W2106665120 @default.
- W2950147893 cites W2107277218 @default.
- W2950147893 cites W2110905563 @default.
- W2950147893 cites W2111378495 @default.
- W2950147893 cites W2113995129 @default.
- W2950147893 cites W2114104545 @default.
- W2950147893 cites W2115852450 @default.
- W2950147893 cites W2117757143 @default.
- W2950147893 cites W2122359326 @default.
- W2950147893 cites W2124614845 @default.
- W2950147893 cites W2126496132 @default.
- W2950147893 cites W2138891173 @default.
- W2950147893 cites W2143072711 @default.
- W2950147893 cites W2153643905 @default.
- W2950147893 cites W2157031657 @default.
- W2950147893 cites W2158485828 @default.
- W2950147893 cites W2158789637 @default.
- W2950147893 cites W2163353298 @default.
- W2950147893 cites W2167279371 @default.
- W2950147893 cites W2169456326 @default.
- W2950147893 cites W2170189990 @default.
- W2950147893 cites W2171808845 @default.
- W2950147893 cites W2259938310 @default.
- W2950147893 cites W2320366601 @default.
- W2950147893 cites W2323851578 @default.
- W2950147893 cites W2411937682 @default.
- W2950147893 cites W2461903592 @default.
- W2950147893 cites W2465425712 @default.
- W2950147893 cites W2487549822 @default.
- W2950147893 cites W2518194013 @default.
- W2950147893 cites W2520749639 @default.
- W2950147893 cites W2526226937 @default.
- W2950147893 cites W2531294657 @default.
- W2950147893 cites W2564237126 @default.
- W2950147893 cites W2567168512 @default.
- W2950147893 cites W2757552016 @default.
- W2950147893 cites W2770095154 @default.
- W2950147893 cites W2786741514 @default.
- W2950147893 cites W4230096730 @default.
- W2950147893 doi "https://doi.org/10.1038/s41467-018-04283-9" @default.
- W2950147893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5943456" @default.
- W2950147893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29743479" @default.
- W2950147893 hasPublicationYear "2018" @default.
- W2950147893 type Work @default.