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- W2950148944 abstract "Abstract The cornea plays important roles in the eye, since it maintains the ocular pressure, bears up different aggressions and forces, and constitutes the primary lens in many animals’ eyes. In order to fulfill these extremely crucial functions, the cornea requires sophisticated structures called epithelium, Bowman's membrane, stroma, Descement's layer, and endothelium. The complexity of this tissue is such that despite many efforts, it has not been possible to obtain clinically viable corneas in the lab yet. Vitamin C or l -ascorbic acid is an essential vitamin and a water-soluble important nutrient, which many animals chemically synthesize from the glucose by means of enzymatic reactions, the l -gulono-γ-lactone oxidase being the last enzyme. Among the multiple roles played by this vitamin, its primary functions are to act as a cofactor for reactions requiring a reduced iron or copper metalloenzyme and as a protective antioxidant that operates in the aqueous phases, both intra- and extracellularly. Ocular tissues, particularly the cornea, concentrate vitamin C, which might suggest that the different structures of the cornea need this vitamin to fulfill their roles. In this chapter, we present scientific evidences of ascorbic acid critical roles in maintaining the functions and ultrastructures of the corneal epithelium, the stroma, and the endothelium." @default.
- W2950148944 created "2019-06-27" @default.
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- W2950148944 date "2019-01-01" @default.
- W2950148944 modified "2023-10-14" @default.
- W2950148944 title "New Ultra-Structural Aspects of Cornea: Significance of Ascorbate Micronutrient Deficiency" @default.
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- W2950148944 doi "https://doi.org/10.1016/b978-0-12-815245-4.00036-3" @default.
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