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- W2950149983 abstract "2. Pharmacodynamic Aspects of Design . . . . . . . . . . . 7 2.1. Biochemistry as a Source of Leads . . . . . . . . . . 7 2.1.1. Metabolites and Antimetabolites . . . . . . . . . 7 2.1.2. Antimetabolites with Selectivity in Action . . . . . 9 2.1.3. The Point of Attack in the Metabolic Pathway . . . . 11 2.2. Screening of Natural Products and Synthetics for Bioactivity. 12 2.2.1. Separation of Therapeutic Action from Unwanted Action. 12 2.2.2. From Side-Effect to Therapeutic Effect . . . . . . 13 2.3. Bioactive Drug Metabolites . . . . . . . . . . . . . 16 2.3.1. Biotoxification . . . . . . . . . . . . . . . 17 2.3.2. Half-Life of Pharmaca as a Funct ion of Metabolic Inactivation Versus Renal Excretion . . . . . . . . 22 2.3.3. Avoidance of Biotoxification in the Design Procedure . 24" @default.
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- W2950149983 date "1975-01-14" @default.
- W2950149983 modified "2023-09-27" @default.
- W2950149983 title "ChemInform Abstract: DESIGN OF BIOACTIVE COMPOUNDS" @default.
- W2950149983 doi "https://doi.org/10.1002/chin.197502454" @default.
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