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• W2950153040 abstract "Abstract In vivo , the human genome folds into a characteristic ensemble of three-dimensional structures. The mechanism driving the folding process remains unknown. We report a theoretical model for chromatin ( Mi nimal Chro matin M odel) that explains the folding of interphase chromosomes and generates chromosome conformations consistent with experimental data. The energy landscape of the model was derived by using the maximum entropy principle and relies on two experimentally derived inputs: a classification of loci into chromatin types and a catalog of the positions of chromatin loops. First, we trained our energy function using the Hi-C contact map of chromosome 10 from human GM12878 lymphoblastoid cells. Then we used the model to perform molecular dynamics simulations producing an ensemble of 3D structures for all GM12878 autosomes. Finally, we used these 3D structures to generate contact maps. We found that simulated contact maps closely agree with experimental results for all GM12878 autosomes. The ensemble of structures resulting from these simulations exhibited unknotted chromosomes, phase separation of chromatin types, and a tendency for open chromatin to lie at the periphery of chromosome territories. One Sentence Summary: We report a model for chromatin that explains and accurately reproduces the three-dimensional structure of chromosomes in interphase." @default.
• W2950153040 created "2019-06-27" @default.
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• W2950153040 date "2016-04-13" @default.
• W2950153040 modified "2023-10-06" @default.
• W2950153040 title "A Transferable Model For Chromosome Architecture" @default.
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• W2950153040 doi "https://doi.org/10.1101/048439" @default.
• W2950153040 hasPublicationYear "2016" @default.
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