FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950167983> ?p ?o ?g. }

• W2950167983 abstract "The timing of Drosophila egg chamber development is controlled by a germline Delta signal that activates Notch in the follicle cells to induce them to cease proliferation and differentiate. Here we report that follicle cells lacking the RNA-binding protein IMP go through one extra division due to a delay in the Delta-dependent S2 cleavage of Notch. The timing of Notch activation has previously been shown to be controlled by cis-inhibition by Delta in the follicle cells, which is relieved when the miRNA pathway represses Delta expression. imp mutants are epistatic to Delta mutants and give an additive phenotype with belle and dicer mutants, indicating that IMP functions independently of both cis-inhibition and the miRNA pathway. We find that the imp phenotype is rescued by over-expression of Kuzbanian, the metalloprotease that mediates the Notch S2 cleavage. Furthermore, Kuzbanian is not enriched at the apical membrane in imp mutants, accumulating instead in late endosomes. Thus, IMP regulates Notch signalling by controlling the localisation of Kuzbanian to the apical domain, where Notch cleavage occurs, revealing a novel regulatory step in the Notch pathway." @default.
• W2950167983 created "2019-06-27" @default.
• W2950167983 creator A5017726721 @default.
• W2950167983 creator A5027640574 @default.
• W2950167983 creator A5042234587 @default.
• W2950167983 date "2019-01-01" @default.
• W2950167983 modified "2023-09-27" @default.
• W2950167983 title "<i>Drosophila</i>IMP regulates Kuzbanian to control the timing of Notch signalling in the follicle cells" @default.
• W2950167983 cites W1595935608 @default.
• W2950167983 cites W1652763473 @default.
• W2950167983 cites W1655397332 @default.
• W2950167983 cites W1675105744 @default.
• W2950167983 cites W1855259954 @default.
• W2950167983 cites W1873165927 @default.
• W2950167983 cites W1897178313 @default.
• W2950167983 cites W1964633462 @default.
• W2950167983 cites W1965472723 @default.
• W2950167983 cites W1969412365 @default.
• W2950167983 cites W1982726261 @default.
• W2950167983 cites W1984075220 @default.
• W2950167983 cites W1984219521 @default.
• W2950167983 cites W1985972808 @default.
• W2950167983 cites W1986679962 @default.
• W2950167983 cites W1989624726 @default.
• W2950167983 cites W1990803574 @default.
• W2950167983 cites W1991469669 @default.
• W2950167983 cites W1993575479 @default.
• W2950167983 cites W1996303419 @default.
• W2950167983 cites W1999177329 @default.
• W2950167983 cites W2006229889 @default.
• W2950167983 cites W2009702490 @default.
• W2950167983 cites W2015279698 @default.
• W2950167983 cites W2015764953 @default.
• W2950167983 cites W2021097106 @default.
• W2950167983 cites W2031781345 @default.
• W2950167983 cites W2040774413 @default.
• W2950167983 cites W2046635810 @default.
• W2950167983 cites W2050956563 @default.
• W2950167983 cites W2051944835 @default.
• W2950167983 cites W2062206747 @default.
• W2950167983 cites W2062921431 @default.
• W2950167983 cites W2066157267 @default.
• W2950167983 cites W2074584250 @default.
• W2950167983 cites W2082362642 @default.
• W2950167983 cites W2083425643 @default.
• W2950167983 cites W2084520007 @default.
• W2950167983 cites W2090817340 @default.
• W2950167983 cites W2091549056 @default.
• W2950167983 cites W2101402754 @default.
• W2950167983 cites W2103235250 @default.
• W2950167983 cites W2107014746 @default.
• W2950167983 cites W2108325176 @default.
• W2950167983 cites W2108534007 @default.
• W2950167983 cites W2109729540 @default.
• W2950167983 cites W2110287546 @default.
• W2950167983 cites W2116813067 @default.
• W2950167983 cites W2117720293 @default.
• W2950167983 cites W2118642448 @default.
• W2950167983 cites W2120525124 @default.
• W2950167983 cites W2129096575 @default.
• W2950167983 cites W2131387714 @default.
• W2950167983 cites W2135685454 @default.
• W2950167983 cites W2136065795 @default.
• W2950167983 cites W2138708625 @default.
• W2950167983 cites W2138957442 @default.
• W2950167983 cites W2141238987 @default.
• W2950167983 cites W2142603652 @default.
• W2950167983 cites W2149008219 @default.
• W2950167983 cites W2154996517 @default.
• W2950167983 cites W2159418321 @default.
• W2950167983 cites W2162097271 @default.
• W2950167983 cites W2162271468 @default.
• W2950167983 cites W2164898869 @default.
• W2950167983 cites W2166225419 @default.
• W2950167983 cites W2168253930 @default.
• W2950167983 cites W2168948134 @default.
• W2950167983 cites W2182689882 @default.
• W2950167983 cites W2225257929 @default.
• W2950167983 cites W2332075290 @default.
• W2950167983 cites W2422056531 @default.
• W2950167983 cites W2487549822 @default.
• W2950167983 cites W2560556363 @default.
• W2950167983 cites W2774459534 @default.
• W2950167983 cites W4230963859 @default.
• W2950167983 cites W4297627084 @default.
• W2950167983 doi "https://doi.org/10.1242/dev.168963" @default.
• W2950167983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6361131" @default.
• W2950167983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30635283" @default.
• W2950167983 hasPublicationYear "2019" @default.
• W2950167983 type Work @default.
• W2950167983 sameAs 2950167983 @default.
• W2950167983 citedByCount "4" @default.
• W2950167983 countsByYear W29501679832019 @default.
• W2950167983 countsByYear W29501679832020 @default.
• W2950167983 countsByYear W29501679832022 @default.
• W2950167983 crossrefType "journal-article" @default.
• W2950167983 hasAuthorship W2950167983A5017726721 @default.
• W2950167983 hasAuthorship W2950167983A5027640574 @default.
• W2950167983 hasAuthorship W2950167983A5042234587 @default.
• W2950167983 hasBestOaLocation W29501679831 @default.

• next