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• W2950168100 abstract "Colitis-associated colon cancer (CAC) is a widely recognized cancer, while treatment with the existing chemotherapeutic drugs affords limited clinical benefits. Herein we proposed a site-specific, combination nanotherapy strategy for targeted treatment of CAC by the oral route. Methods: A reactive oxygen species (ROS)-responsive and hydrogen peroxide-eliminating material OCD was synthesized, which was further produced into a functional nanoparticle (OCD NP). The antioxidative stress and anti-inflammatory effects of OCD NP were examined by in vitro and in vivo experiments. By packaging an anticancer drug camptothecin-11 (CPT-11) into OCD NP, a ROS-responsive nanotherapy CPT-11/OCD NP was obtained, and its antitumor activity was evaluated by both in vitro and in vivo studies. Preliminary safety studies were also performed for CPT-11/OCD NP in mice. Results: OCD NP significantly attenuated oxidative stress and inhibited inflammatory response in different cells and mice with induced colitis. CPT-11/OCD NP could selectively release drug molecules under intestinal pH conditions and at high levels of ROS. In C26 murine colon carcinoma cells, this nanotherapy showed significantly higher antitumor activity compared to free CPT-11 and a non-responsive CPT-11 nanotherapy. Correspondingly, oral delivery of CPT-11/OCD NP notably inhibited tumorigenesis and tumor growth in mice with induced CAC. By combination therapy with the nanovehicle OCD NP in the inflammatory phase, more desirable therapeutic effects were achieved. Furthermore, CPT-11/OCD NP displayed excellent safety profile for oral administration at a dose that is 87.3-fold higher than that employed in therapeutic studies. Conclusions: Anticancer nanotherapies derived from intrinsic anti-inflammatory nanocarriers are promising for targeted combination treatment of inflammation-associated tumors by simultaneously shaping pro-inflammatory microenvironment toward a relatively normal niche sensitive to chemotherapy." @default.
• W2950168100 created "2019-06-27" @default.
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• W2950168100 date "2019-01-01" @default.
• W2950168100 modified "2023-10-13" @default.
• W2950168100 title "A Multifunctional Nanotherapy for Targeted Treatment of Colon Cancer by Simultaneously Regulating Tumor Microenvironment" @default.
• W2950168100 cites W1752031980 @default.
• W2950168100 cites W1909116856 @default.
• W2950168100 cites W1964836370 @default.
• W2950168100 cites W1965037168 @default.
• W2950168100 cites W1966704219 @default.
• W2950168100 cites W1966802906 @default.
• W2950168100 cites W1981335658 @default.
• W2950168100 cites W1986406665 @default.
• W2950168100 cites W1997944110 @default.
• W2950168100 cites W2001570602 @default.
• W2950168100 cites W2003110090 @default.
• W2950168100 cites W2010220086 @default.
• W2950168100 cites W2011366548 @default.
• W2950168100 cites W2018247165 @default.
• W2950168100 cites W2018293352 @default.
• W2950168100 cites W2018983895 @default.
• W2950168100 cites W2019867999 @default.
• W2950168100 cites W2023281683 @default.
• W2950168100 cites W2027518405 @default.
• W2950168100 cites W2035687675 @default.
• W2950168100 cites W2040206306 @default.
• W2950168100 cites W2040978052 @default.
• W2950168100 cites W2043647235 @default.
• W2950168100 cites W2044609602 @default.
• W2950168100 cites W2048025500 @default.
• W2950168100 cites W2051247936 @default.
• W2950168100 cites W2051994734 @default.
• W2950168100 cites W2057053889 @default.
• W2950168100 cites W2060891978 @default.
• W2950168100 cites W2069043245 @default.
• W2950168100 cites W2076747298 @default.
• W2950168100 cites W2082490680 @default.
• W2950168100 cites W2106315777 @default.
• W2950168100 cites W2112055293 @default.
• W2950168100 cites W2118278569 @default.
• W2950168100 cites W2119554522 @default.
• W2950168100 cites W2123105952 @default.
• W2950168100 cites W2141145485 @default.
• W2950168100 cites W2145189896 @default.
• W2950168100 cites W2147694344 @default.
• W2950168100 cites W2149746825 @default.
• W2950168100 cites W2171465492 @default.
• W2950168100 cites W2172260616 @default.
• W2950168100 cites W2187839720 @default.
• W2950168100 cites W2192637105 @default.
• W2950168100 cites W2208328112 @default.
• W2950168100 cites W2257473733 @default.
• W2950168100 cites W2320482766 @default.
• W2950168100 cites W2396730683 @default.
• W2950168100 cites W2400724183 @default.
• W2950168100 cites W2414279676 @default.
• W2950168100 cites W2486594993 @default.
• W2950168100 cites W2490710160 @default.
• W2950168100 cites W2492485185 @default.
• W2950168100 cites W2511102702 @default.
• W2950168100 cites W2512738820 @default.
• W2950168100 cites W2530227005 @default.
• W2950168100 cites W2534966454 @default.
• W2950168100 cites W2547438882 @default.
• W2950168100 cites W2607402714 @default.
• W2950168100 cites W2613929012 @default.
• W2950168100 cites W2620756707 @default.
• W2950168100 cites W2624317658 @default.
• W2950168100 cites W2739995305 @default.
• W2950168100 cites W2781594251 @default.
• W2950168100 cites W2787908868 @default.
• W2950168100 cites W2791102190 @default.
• W2950168100 cites W2795176771 @default.
• W2950168100 cites W2800750796 @default.
• W2950168100 cites W2801089752 @default.
• W2950168100 cites W2802433717 @default.
• W2950168100 cites W2805734067 @default.
• W2950168100 cites W2808318674 @default.
• W2950168100 cites W2891562695 @default.
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• W2950168100 doi "https://doi.org/10.7150/thno.34377" @default.
• W2950168100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6587349" @default.
• W2950168100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31281510" @default.
• W2950168100 hasPublicationYear "2019" @default.
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