FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950192435> ?p ?o ?g. }

• W2950192435 abstract "Inflammation and programmed necrosis (necroptosis) are the two hallmark pathological changes after traumatic brain injury (TBI) that contribute to aggravated brain damage. 2-(2-Benzofuranyl)-2-imidazoline (2-BFI) has been shown to exert both anti-inflammatory and programmed cell death effects. Therefore, the aim of the present study was to evaluate the potential beneficial effects of 2-BFI in a rat model of TBI induced by a weight-drop device. 2-BFI or vehicle was given via intraperitoneal injection starting at 30 min post trauma and then twice daily for three consecutive days. Following a neurofunctional test at 72 h after injury, histological, molecular, and immunohistochemistry analyses were performed on the pericontusional areas of the brain. 2-BFI treatment significantly attenuated neurological deficits, brain edema and blood-brain barrier permeability after TBI. Also, treatment with 2-BFI significantly reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine interleukin (IL)-1β secretion, which is related to nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation after TBI. In addition, 2-BFI treatment markedly reduced cortical tissue loss as well as repressed TBI-induced increases in necroptosis and necroptosis-associated proteins, including receptor-interacting protein (RIP1), RIP3, and mixed linkage kinase domain-like (MLKL) in the pericontusional brain tissue. Taken together, these findings indicate that 2-BFI may be an effective neuroprotectant after brain trauma and warrants further study." @default.
• W2950192435 created "2019-06-27" @default.
• W2950192435 creator A5002106325 @default.
• W2950192435 creator A5015506184 @default.
• W2950192435 creator A5020413501 @default.
• W2950192435 creator A5045067652 @default.
• W2950192435 creator A5052992027 @default.
• W2950192435 creator A5080141140 @default.
• W2950192435 date "2019-06-26" @default.
• W2950192435 modified "2023-09-23" @default.
• W2950192435 title "2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury" @default.
• W2950192435 cites W1954155767 @default.
• W2950192435 cites W1964574311 @default.
• W2950192435 cites W1966308623 @default.
• W2950192435 cites W1966483255 @default.
• W2950192435 cites W1969927114 @default.
• W2950192435 cites W1972413031 @default.
• W2950192435 cites W1976141012 @default.
• W2950192435 cites W1981649246 @default.
• W2950192435 cites W1983078635 @default.
• W2950192435 cites W1987907879 @default.
• W2950192435 cites W1998983498 @default.
• W2950192435 cites W2000965529 @default.
• W2950192435 cites W2009178440 @default.
• W2950192435 cites W2011398156 @default.
• W2950192435 cites W2017688638 @default.
• W2950192435 cites W2022062858 @default.
• W2950192435 cites W2022297536 @default.
• W2950192435 cites W2026209203 @default.
• W2950192435 cites W2038291815 @default.
• W2950192435 cites W2052249006 @default.
• W2950192435 cites W2058653746 @default.
• W2950192435 cites W2068462003 @default.
• W2950192435 cites W2077956987 @default.
• W2950192435 cites W2084969905 @default.
• W2950192435 cites W2132161879 @default.
• W2950192435 cites W2139552156 @default.
• W2950192435 cites W2140729052 @default.
• W2950192435 cites W2146373526 @default.
• W2950192435 cites W2159679709 @default.
• W2950192435 cites W2198738464 @default.
• W2950192435 cites W2319054200 @default.
• W2950192435 cites W2338879034 @default.
• W2950192435 cites W2519065143 @default.
• W2950192435 cites W2582594972 @default.
• W2950192435 cites W2595647051 @default.
• W2950192435 cites W2735978036 @default.
• W2950192435 cites W2737259005 @default.
• W2950192435 cites W2766236939 @default.
• W2950192435 cites W2769599719 @default.
• W2950192435 cites W2790287228 @default.
• W2950192435 cites W2792394746 @default.
• W2950192435 cites W2792602478 @default.
• W2950192435 cites W2792823719 @default.
• W2950192435 cites W2801626566 @default.
• W2950192435 cites W2807221969 @default.
• W2950192435 cites W2894437797 @default.
• W2950192435 cites W2896295786 @default.
• W2950192435 cites W66898540 @default.
• W2950192435 doi "https://doi.org/10.3389/fnins.2019.00674" @default.
• W2950192435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6606784" @default.
• W2950192435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31293382" @default.
• W2950192435 hasPublicationYear "2019" @default.
• W2950192435 type Work @default.
• W2950192435 sameAs 2950192435 @default.
• W2950192435 citedByCount "23" @default.
• W2950192435 countsByYear W29501924352019 @default.
• W2950192435 countsByYear W29501924352020 @default.
• W2950192435 countsByYear W29501924352021 @default.
• W2950192435 countsByYear W29501924352022 @default.
• W2950192435 countsByYear W29501924352023 @default.
• W2950192435 crossrefType "journal-article" @default.
• W2950192435 hasAuthorship W2950192435A5002106325 @default.
• W2950192435 hasAuthorship W2950192435A5015506184 @default.
• W2950192435 hasAuthorship W2950192435A5020413501 @default.
• W2950192435 hasAuthorship W2950192435A5045067652 @default.
• W2950192435 hasAuthorship W2950192435A5052992027 @default.
• W2950192435 hasAuthorship W2950192435A5080141140 @default.
• W2950192435 hasBestOaLocation W29501924351 @default.
• W2950192435 hasConcept C118552586 @default.
• W2950192435 hasConcept C126322002 @default.
• W2950192435 hasConcept C139174496 @default.
• W2950192435 hasConcept C164027704 @default.
• W2950192435 hasConcept C169760540 @default.
• W2950192435 hasConcept C190283241 @default.
• W2950192435 hasConcept C25498285 @default.
• W2950192435 hasConcept C2776914184 @default.
• W2950192435 hasConcept C2777209026 @default.
• W2950192435 hasConcept C2781017439 @default.
• W2950192435 hasConcept C2781458332 @default.
• W2950192435 hasConcept C31573885 @default.
• W2950192435 hasConcept C55493867 @default.
• W2950192435 hasConcept C71924100 @default.
• W2950192435 hasConcept C86803240 @default.
• W2950192435 hasConcept C87753298 @default.
• W2950192435 hasConcept C94030615 @default.
• W2950192435 hasConcept C98274493 @default.
• W2950192435 hasConceptScore W2950192435C118552586 @default.
• W2950192435 hasConceptScore W2950192435C126322002 @default.
• W2950192435 hasConceptScore W2950192435C139174496 @default.

• next