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- W2950206871 abstract "Quinolones are widely used broad-spectrum antibacterials with incomplete elucidated mechanism of action. Here, molecular basis for the antibacterial action of quinolones, from target to network, is fully discussed and updated. Quinolones trap DNA gyrase or topoisomerase IV to form reversible drug-enzyme-DNA cleavage complexes, resulting in bacteriostasis. Cell death arises from chromosome fragmentation in protein synthesis-dependent or -independent pathways according to distinguished quinolone structures. In the former pathway, irreversible oxidative DNA damage caused by reactive oxygen species kills bacteria eventually. Toxin-antitoxin mazEF is triggered as an additional lethal action. Bacteria survive and develop resistance by SOS and other stress responses. Enlarged knowledges of quinolone actions and bacterial response will provide new targets for drug design and approaches to prevent bacterial resistance." @default.
- W2950206871 created "2019-06-27" @default.
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- W2950206871 date "2013-10-01" @default.
- W2950206871 modified "2023-09-22" @default.
- W2950206871 title "ChemInform Abstract: Antibacterial Action of Quinolones: From Target to Network" @default.
- W2950206871 cites W2015428602 @default.
- W2950206871 doi "https://doi.org/10.1002/chin.201342235" @default.
- W2950206871 hasPublicationYear "2013" @default.
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