Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950207866> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2950207866 endingPage "1240" @default.
- W2950207866 startingPage "1215" @default.
- W2950207866 abstract "This account describes our efforts aimed toward the discovery of original glycomimetics that target protein misfolding to fight rare diseases, with a focus on cystic fibrosis and Gaucher disease. The pursuit of this goal has led to promising leads and strategies, with the first description of a multivalent effect for correcting protein-folding defects in cells, and has also driven unexpected progress in synthetic methodology. 1 Introduction 2 The Therapeutic Targets: Challenges and Stakes 2.1 Glycosphingolipid Lysosomal Storage Disorders 2.2 Cystic Fibrosis 3 Synthetic Targets Met, Potent Leads Gained 3.1 Synthetic Targets Met 3.2 A First Detour via a Substrate Reduction Therapy Approach 3.3 Potent Leads Gained 4 Synthetic Targets Missed, Synthetic Progress Gained 4.1 A New Domino Reaction 4.2 Extending the Scope of C–H Amination 4.3 A New Versatile Amino Protecting Group 5 Multivalency: A New and Promising Approach 5.1 How It Began 5.2 Gaucher Disease 5.3 Cystic Fibrosis 6 Conclusion" @default.
- W2950207866 created "2019-06-27" @default.
- W2950207866 creator A5041553746 @default.
- W2950207866 date "2014-03-14" @default.
- W2950207866 modified "2023-09-25" @default.
- W2950207866 title "Searching for Glycomimetics That Target Protein Misfolding in Rare Diseases: Successes, Failures, and Unexpected Progress Made in Organic Synthesis" @default.
- W2950207866 doi "https://doi.org/10.1055/s-0033-1340822" @default.
- W2950207866 hasPublicationYear "2014" @default.
- W2950207866 type Work @default.
- W2950207866 sameAs 2950207866 @default.
- W2950207866 citedByCount "24" @default.
- W2950207866 countsByYear W29502078662014 @default.
- W2950207866 countsByYear W29502078662015 @default.
- W2950207866 countsByYear W29502078662016 @default.
- W2950207866 countsByYear W29502078662017 @default.
- W2950207866 countsByYear W29502078662018 @default.
- W2950207866 countsByYear W29502078662019 @default.
- W2950207866 countsByYear W29502078662020 @default.
- W2950207866 countsByYear W29502078662021 @default.
- W2950207866 countsByYear W29502078662023 @default.
- W2950207866 crossrefType "journal-article" @default.
- W2950207866 hasAuthorship W2950207866A5041553746 @default.
- W2950207866 hasConcept C126322002 @default.
- W2950207866 hasConcept C15744967 @default.
- W2950207866 hasConcept C161790260 @default.
- W2950207866 hasConcept C169760540 @default.
- W2950207866 hasConcept C171250308 @default.
- W2950207866 hasConcept C181199279 @default.
- W2950207866 hasConcept C185592680 @default.
- W2950207866 hasConcept C192562407 @default.
- W2950207866 hasConcept C204328495 @default.
- W2950207866 hasConcept C21951064 @default.
- W2950207866 hasConcept C2776938444 @default.
- W2950207866 hasConcept C2779938440 @default.
- W2950207866 hasConcept C2908579795 @default.
- W2950207866 hasConcept C55493867 @default.
- W2950207866 hasConcept C70721500 @default.
- W2950207866 hasConcept C71924100 @default.
- W2950207866 hasConcept C74187038 @default.
- W2950207866 hasConcept C86803240 @default.
- W2950207866 hasConceptScore W2950207866C126322002 @default.
- W2950207866 hasConceptScore W2950207866C15744967 @default.
- W2950207866 hasConceptScore W2950207866C161790260 @default.
- W2950207866 hasConceptScore W2950207866C169760540 @default.
- W2950207866 hasConceptScore W2950207866C171250308 @default.
- W2950207866 hasConceptScore W2950207866C181199279 @default.
- W2950207866 hasConceptScore W2950207866C185592680 @default.
- W2950207866 hasConceptScore W2950207866C192562407 @default.
- W2950207866 hasConceptScore W2950207866C204328495 @default.
- W2950207866 hasConceptScore W2950207866C21951064 @default.
- W2950207866 hasConceptScore W2950207866C2776938444 @default.
- W2950207866 hasConceptScore W2950207866C2779938440 @default.
- W2950207866 hasConceptScore W2950207866C2908579795 @default.
- W2950207866 hasConceptScore W2950207866C55493867 @default.
- W2950207866 hasConceptScore W2950207866C70721500 @default.
- W2950207866 hasConceptScore W2950207866C71924100 @default.
- W2950207866 hasConceptScore W2950207866C74187038 @default.
- W2950207866 hasConceptScore W2950207866C86803240 @default.
- W2950207866 hasIssue "09" @default.
- W2950207866 hasLocation W29502078661 @default.
- W2950207866 hasOpenAccess W2950207866 @default.
- W2950207866 hasPrimaryLocation W29502078661 @default.
- W2950207866 hasRelatedWork W2026490663 @default.
- W2950207866 hasRelatedWork W2041719513 @default.
- W2950207866 hasRelatedWork W2089603672 @default.
- W2950207866 hasRelatedWork W2950383669 @default.
- W2950207866 hasRelatedWork W2950772480 @default.
- W2950207866 hasRelatedWork W2952512966 @default.
- W2950207866 hasRelatedWork W3205391401 @default.
- W2950207866 hasRelatedWork W3214711264 @default.
- W2950207866 hasRelatedWork W4235968645 @default.
- W2950207866 hasRelatedWork W4315781845 @default.
- W2950207866 hasVolume "25" @default.
- W2950207866 isParatext "false" @default.
- W2950207866 isRetracted "false" @default.
- W2950207866 magId "2950207866" @default.
- W2950207866 workType "article" @default.